{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:17:24Z","timestamp":1760707044754,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,10,3]],"date-time":"2002-10-03T00:00:00Z","timestamp":1033603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mutations in the <jats:italic>TBX22<\/jats:italic> gene have been identified recently in patients with the X\u2010linked cleft palate and ankyloglossia syndrome, suggesting that the TBX22 transcription factor plays an important role in palate development. However, because ankyloglossia has been reported in the majority of patients with <jats:italic>TBX22<\/jats:italic> mutations, it has been speculated that the cleft palate phenotype is secondary to defective fetal tongue movement. To understand the role of <jats:italic>TBX22<\/jats:italic> in disease pathogenesis and in normal development, it is necessary to carry out a detailed temporal and spatial gene expression analysis. We report here the isolation and developmental expression analysis of the mouse homolog <jats:italic>Tbx22<\/jats:italic>. The mouse <jats:italic>Tbx22<\/jats:italic> gene encodes a putative protein of 517 amino acid residues, which shares 72% overall amino acid sequence identity with the human TBX22 protein. By using interspecific backcross analysis, we have localized the <jats:italic>Tbx22<\/jats:italic> gene to mouse chromosome X, in a region syntenic to human chromosome Xq21, where the <jats:italic>TBX22<\/jats:italic> gene resides, indicating that <jats:italic>Tbx22<\/jats:italic> is the ortholog of human <jats:italic>TBX22<\/jats:italic>. Our in situ hybridization analysis shows that <jats:italic>Tbx22<\/jats:italic> is expressed in a temporally and spatially highly restricted pattern during mouse palate and tongue development. Together with the mutant phenotypes in human patients, our data indicate a primary role for <jats:italic>Tbx22<\/jats:italic> in both palate and tongue development. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.10154","type":"journal-article","created":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T09:16:19Z","timestamp":1036142179000},"page":"322-326","source":"Crossref","is-referenced-by-count":41,"title":["Isolation and developmental expression analysis of <i>Tbx22<\/i>, the mouse homolog of the human X\u2010linked cleft palate gene"],"prefix":"10.1002","volume":"225","author":[{"given":"Jeffrey O.","family":"Bush","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Maltby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rulang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,10,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0797-311"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-30"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng730"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4829"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0283"},{"key":"e_1_2_5_7_1","first-page":"1129","article-title":"The gene responsible for X\u2010linked cleft palate (CPX) in a British Columbia native kindred is localized between PGK1 and DXYS1","volume":"50","author":"Gorski SM","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/85845"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(98)80005-5"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00282-3"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00457-9"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(00)00326-7"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/35065105"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00247-1"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.7.4.315"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(01)07002-4"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(199801)20:1<9::AID-BIES4>3.0.CO;2-Q"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.1.79"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1370"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.8.915"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.10154","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.10154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T18:46:02Z","timestamp":1760381162000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.10154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1002\/dvdy.10154"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.10154","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"type":"print","value":"1058-8388"},{"type":"electronic","value":"1097-0177"}],"subject":[],"published":{"date-parts":[[2002,10,3]]}}}