{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:01:39Z","timestamp":1789750899799,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,11,11]],"date-time":"2002-11-11T00:00:00Z","timestamp":1036972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Helix\u2010loop\u2010helix (HLH) genes function as important regulators of neurogenesis in both the peripheral and central nervous systems. The olfactory system is an ideal tissue in which to study the role of these genes in regulating the acquisition of neuronal cell fate, particularly that of the olfactory receptor neuron (ORN). Here we describe the expression of several basic HLH (bHLH) and repeat HLH (rHLH) factors during olfactory placode development in\n                    <jats:italic>Xenopus laevis<\/jats:italic>\n                    . Our work reveals that a combination of both bHLH and rHLH genes are sequentially expressed within the nascent olfactory placode during normal development. Moreover, overexpression of the bHLH factor,\n                    <jats:italic>Xenopus<\/jats:italic>\n                    atonal homologue 5 (Xath5), promotes olfactory neural fate independent of cellular proliferation within a restricted domain at the anterior of the embryo. Collectively, our data argue that HLH genes are expressed in a cascade during olfactory placode development and that the activity of an\n                    <jats:italic>atonal<\/jats:italic>\n                    homologue, Xath5, can promote ORN fate but only in the appropriate developmental context. \u00a9 2002 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/dvdy.10189","type":"journal-article","created":{"date-parts":[[2002,12,2]],"date-time":"2002-12-02T08:54:09Z","timestamp":1038819249000},"page":"536-543","source":"Crossref","is-referenced-by-count":22,"title":["Xath5 regulates neurogenesis in the\n                    <i>Xenopus<\/i>\n                    olfactory placode"],"prefix":"10.1002","volume":"225","author":[{"given":"Carole J.","family":"Burns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica L.","family":"Vetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,11,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(98)00144-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn874"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.23.4821"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90418-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90351-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90120-7"},{"key":"e_1_2_6_8_1","first-page":"267","article-title":"Neurogenesis in Drosophila: an historical perspective and some prospects","volume":"4","author":"Campos\u2010Ortega JA","year":"1997","journal-title":"Perspect Dev Neurobiol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.8.1611"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.11.2323"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.8.1871"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)80003-8"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/375761a0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00486-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70084-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480210305"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.12.3649"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1242\/jeb.204.12.2049","article-title":"Differential and overlapping expression patterns of X\u2010dll3 and Pax\u20106 genes suggest distinct roles in olfactory system development of the African clawed frog Xenopus laevis","volume":"204","author":"Franco MD","year":"2001","journal-title":"J Exp Biol"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199711)210:3<191::AID-AJA1>3.0.CO;2-B"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01606-4"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90381-Y"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.1997.d01-312.x"},{"key":"e_1_2_6_23_1","first-page":"289","article-title":"Denervationin the primary olfactory pathway of mice. 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