{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T10:45:29Z","timestamp":1774694729490,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,2,28]],"date-time":"2003-02-28T00:00:00Z","timestamp":1046390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>TBX22<\/jats:italic> belongs to the T\u2010box family of transcription factors and was originally found in an in silico approach designed to identify new genes on the human Xq12\u2010q21 region. Mutations in <jats:italic>TBX22<\/jats:italic> have been reported in families with X\u2010linked cleft palate and ankyloglossia (CPX), but the underlying pathogenetic mechanism remained unknown. We have identified mouse <jats:italic>Tbx22<\/jats:italic> and analyzed its expression during embryogenesis by reverse transcriptase\u2010polymerase chain reaction and in situ hybridization. In mouse embryos, it is expressed in distinct areas of the head, namely the mesenchyme of the inferior nasal septum, the posterior palatal shelf before fusion, the attachment of the tongue, and mesenchymal cells surrounding the eye anlage. The localization in the tongue frenulum perfectly correlates with the ankyloglossia phenotype in CPX. Furthermore, we identified positionally conserved binding sites for transcription factors, two of which have been implicated previously in palatogenesis (MSX1, PRX2). Developmental Dynamics 226:579\u2013586, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.10260","type":"journal-article","created":{"date-parts":[[2003,3,26]],"date-time":"2003-03-26T06:58:43Z","timestamp":1048661923000},"page":"579-586","source":"Crossref","is-referenced-by-count":29,"title":["Expression of mouse <i>Tbx22<\/i> supports its role in palatogenesis and 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