{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:04:55Z","timestamp":1761523495176,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,7,29]],"date-time":"2003-07-29T00:00:00Z","timestamp":1059436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pharyngeal arch artery (PAA) remodeling defects account for several cases of congenital heart disease. Mutations in the Endothelin\u20101 genetic pathway or <jats:italic>Tbx1<\/jats:italic>, a candidate \ngene for DiGeorge syndrome, cause similar aortic arch defects. Previous research suggests that Tbx1 may trigger diffusible signals from the pharyngeal arches to support the growth of the PAAs that \ncontribute to the mature aortic arch. The demonstration of genetic interaction between <jats:italic>Tbx1<\/jats:italic> and <jats:italic>Fgf8<\/jats:italic> pointed to FGF signaling as a possible candidate. Because <jats:italic>Fgf8<\/jats:italic> interacts with \nEndothelin\u20101 signaling and because Endothelin\u20101 signaling interacts with neural crest\u2010derived cells in the pharyngeal apparatus, we hypothesized that <jats:italic>Tbx1<\/jats:italic> and \nEndothelin\u20101 signaling may contribute to the same pathway required for aortic arch morphogenesis. Therefore, we have analyzed mice mutated for the endothelin converting enzyme \n(<jats:italic>Ece1<\/jats:italic>) or <jats:italic>Tbx1<\/jats:italic> genes and compound mutants. Results show that the two genes have different roles in the remodeling of the PAAs and do not interact. We propose that <jats:italic>Tbx1<\/jats:italic> \nis required for the formation and early growth and remodeling of the PAAs, whereas <jats:italic>Ece1<\/jats:italic> is necessary for regression of the cranial arch arteries and growth of the most caudal arch arteries. The \nlatter function is likely related to the known role of the Endothelin\u20101 pathway in neural crest function. Developmental Dynamics 228:95\u2013104, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.10358","type":"journal-article","created":{"date-parts":[[2003,8,26]],"date-time":"2003-08-26T11:24:24Z","timestamp":1061897064000},"page":"95-104","source":"Crossref","is-referenced-by-count":13,"title":["<i>Ece1<\/i> and <i>Tbx1<\/i> define distinct pathways to aortic arch morphogenesis"],"prefix":"10.1002","volume":"228","author":[{"given":"Masae","family":"Morishima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,7,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1242\/dev.129.19.4613","article-title":"Fgf8 is required for pharyngeal arch development and cardiovascular patterning in the mouse","volume":"129","author":"Abu\u2010Issa R","year":"2002","journal-title":"Development"},{"key":"e_1_2_6_3_1","first-page":"23","volume-title":"Molecular and cellular methods in developmental toxicology","author":"Albrecht U","year":"1997"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092250306"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.5.813"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9527"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00128-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.19.4591"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/85845"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0819"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/368703a0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199506263-00005"},{"key":"e_1_2_6_13_1","first-page":"639","article-title":"Endothelin and neural crest development","volume":"45","author":"Kurihara H","year":"1999","journal-title":"Cell Mol Biol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.9.997"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/43900"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/35065105"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00247-1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-1738(01)00140-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.4.1089"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.7.3058"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.23.3136"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.8.915"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.19.4605"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2698"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.5.825"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7447"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.10358","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.10358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:32:57Z","timestamp":1760347977000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.10358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,29]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1002\/dvdy.10358"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.10358","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"type":"print","value":"1058-8388"},{"type":"electronic","value":"1097-0177"}],"subject":[],"published":{"date-parts":[[2003,7,29]]}}}