{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:40:44Z","timestamp":1772757644008,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,11,5]],"date-time":"2003-11-05T00:00:00Z","timestamp":1067990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Full\u2010length cDNA coding for the <jats:italic>ictacalcin<\/jats:italic> gene, a homolog of the <jats:italic>S100<\/jats:italic> genes, was isolated in zebrafish and mapped on linkage group 16 using the LN54 radiation hybrid panel. The homology and phylogenetic analyses, based on the deduced amino acid sequences, showed the orthologous relationship of <jats:italic>ictacalcin<\/jats:italic> genes between zebrafish and other fish species. However, <jats:italic>ictacalcin<\/jats:italic> genes constitute an out\u2010group with respect to other members of the <jats:italic>S100<\/jats:italic> gene family. This result supports the findings that fish <jats:italic>ictacalcin<\/jats:italic> genes are new members of the <jats:italic>S100<\/jats:italic> gene family and may have evolved after the divergence of teleosts and tetrapods. The zebrafish <jats:italic>ictacalcin<\/jats:italic> gene was zygotically transcribed from 12 hours postfertilization onward and was stably expressed throughout adulthood. During zebrafish embryogenesis, the <jats:italic>ictacalcin<\/jats:italic> gene was specifically expressed in striated epidermal cells covering the entire embryo. The <jats:italic>ictacalcin<\/jats:italic> staining in keratinocytes of striated epithelia was absent in the cytoplasm surrounding the nuclei, but it was highly concentrated in the peripheral margin. Tissues enriched with epithelia folds, such as olfactory epithelium, hatching gland, pectoral fin buds, urogenital opening, and pharynx, showed a robust <jats:italic>ictacalcin<\/jats:italic> expression. The strikingly heavy staining of <jats:italic>ictacalcin<\/jats:italic> in the pharyngeal region provides us with an early marker to follow the pharynx formation in zebrafish embryos. Developmental Dynamics 228:751\u2013766, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.10411","type":"journal-article","created":{"date-parts":[[2003,12,2]],"date-time":"2003-12-02T09:21:41Z","timestamp":1070356901000},"page":"745-750","source":"Crossref","is-referenced-by-count":21,"title":["Skin\u2010specific expression of <i>ictacalcin<\/i>, a homolog of the <i>S100<\/i> genes, during zebrafish embryogenesis"],"prefix":"10.1002","volume":"228","author":[{"given":"Chung\u2010Der","family":"Hsiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Ekker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huai\u2010Jen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,11,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(94)90237-2"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(00)00406-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051112"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10051"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.title.82144"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040-8166(88)90015-8"},{"key":"e_1_2_5_8_1","first-page":"5161","article-title":"Isolation and expression of two zebrafish homologues of parvalbumin genes related to chicken CPV3 and mammalian oncomodulin","volume":"1195","author":"Hsiao CD","year":"2002","journal-title":"Mech Dev"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10305"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.210601"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0764-4469(97)84816-0"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(93)90004-H"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(02)00414-6"},{"key":"e_1_2_5_14_1","first-page":"449","article-title":"Zebrafish keratin 8 is expressed at high levels in the epidermis of regenerating caudal fin","volume":"45","author":"Martorana ML","year":"2001","journal-title":"Int J Dev Biol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12338501"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00232236"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199903)214:3<207::AID-AJA4>3.0.CO;2-5"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a026165"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(96)00069-1"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.10085"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-9335(98)80074-5"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.2003.700607.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00613.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(00)00473-1"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.22.4673"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(95)00040-2"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.10411","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.10411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T16:02:27Z","timestamp":1760371347000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.10411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,5]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1002\/dvdy.10411"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.10411","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,5]]}}}