{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:17:06Z","timestamp":1792721826540,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,3,2]],"date-time":"2004-03-02T00:00:00Z","timestamp":1078185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Periostin<\/jats:italic> was originally isolated as an osteoblast\u2010specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment, and spreading. The protein was renamed \u201c<jats:italic>periostin<\/jats:italic>\u201d because of its expression in the periosteum and periodontal ligament, indicating a potential role in bone and maintenance of tooth structure. <jats:italic>Periostin<\/jats:italic> has structural similarity to insect <jats:italic>fasciclin\u2010I<\/jats:italic> and can be induced by <jats:italic>TGF\u2010\u03b2<\/jats:italic> and <jats:italic>Bmp2<\/jats:italic>. Because tooth and periodontium development is a well\u2010described genetic model for organogenesis governed by a reciprocal set of epithelial\u2013mesenchymal interactions, thought to be controlled by various <jats:italic>TGF\u2010\u03b2<\/jats:italic> superfamily members, we investigated whether <jats:italic>periostin<\/jats:italic> is present during tooth morphogenesis. Both <jats:italic>periostin<\/jats:italic> mRNA and protein expression were analyzed throughout normal tooth development (embryonic day [E] 9.5\u2013newborn) and within both <jats:italic>Bmp4<\/jats:italic>\u2010 and <jats:italic>Msx2<\/jats:italic>\u2010null embryos. <jats:italic>Periostin<\/jats:italic> mRNA is initially present within the E9.5 first branchial arch epithelium and then shifts to underlying ectomesenchyme. Both mRNA and protein are asymmetrically localized to the lingual\/palatal and buccal side during the early epithelial\u2013mesenchymal interactions. <jats:italic>Periostin<\/jats:italic> is also present in dental papilla cells and within the trans\u2010differentiating odontoblasts during the bell and hard tissue formation stages of tooth development. We suggest that <jats:italic>periostin<\/jats:italic> plays multiple roles as a primary responder molecule during tooth development and may be linked to deposition and organization of other extracellular matrix adhesion molecules during maintenance of the adult tooth, particularly at the sites of hard\u2010soft tissue interface. Developmental Dynamics 229:857\u2013868, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.10453","type":"journal-article","created":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T08:41:11Z","timestamp":1080031271000},"page":"857-868","source":"Crossref","is-referenced-by-count":131,"title":["<i>Periostin<\/i> is expressed within the developing teeth at the sites of epithelial\u2013mesenchymal interaction"],"prefix":"10.1002","volume":"229","author":[{"given":"Agnieszka","family":"Kruzynska\u2010Frejtag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Krug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger R.","family":"Markwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon 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