{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:24:55Z","timestamp":1791271495663,"version":"4.1.0"},"reference-count":211,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,12,10]],"date-time":"2003-12-10T00:00:00Z","timestamp":1071014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The intensity of research on pancreatic development has increased markedly in the past 5 years, primarily for two reasons: we now know that the insulin\u2010producing \u03b2\u2010cells normally arise from an endodermally derived, pancreas\u2010specified precursor cell, and successful transplants of islet cells have been performed, relieving patients with type I diabetes of symptoms for extended periods after transplantation. Combining in vitro \u03b2\u2010cell formation from a pancreatic biopsy of a diabetic patient or from other stem\u2010cell sources followed by endocrine cell transplantation may be the most beneficial route for a future diabetes therapy. However, to achieve this, a thorough understanding of the genetic components regulating the development of \u03b2\u2010cells is required. The following review discusses our current understanding of the transcription factor networks necessary for pancreatic development and how several genetic interactions coming into play at the earliest stages of endodermal development gradually help to build the pancreatic organ. Developmental Dynamics 229:176\u2013200, 2004. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.10460","type":"journal-article","created":{"date-parts":[[2003,12,25]],"date-time":"2003-12-25T04:01:22Z","timestamp":1072324882000},"page":"176-200","source":"Crossref","is-referenced-by-count":311,"title":["Gene regulatory factors in pancreatic development"],"prefix":"10.1002","volume":"229","author":[{"given":"Jan","family":"Jensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"191","volume-title":"Molecular basis of pancreas development and function","author":"Ahlgren U","year":"2001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.5.1409"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/385257a0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.12.1763"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)80016-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9441"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90522-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119.4.1301"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(06)00340-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/23716"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5415.770"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.111.16.2411"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.17.3495"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.21.4795"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.3.450"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(02)00096-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.24.5109"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/316945"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19981115)43:4<332::AID-JEMT7>3.0.CO;2-1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.7.1410"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111272200"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111857200"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.20.2466"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.17.2218"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00035-2"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00459-8"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205905200"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.8.1819"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.4.1933"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.21.4785"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.8.1829"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.269003"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90033-7"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.280.5.L823"},{"key":"e_1_2_6_36_1","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1101\/gad.939601","article-title":"Transcriptional repression: the long and the short of it","volume":"15","author":"Courey AJ","year":"2001","journal-title":"Genes Dev"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950190905"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.12.6923"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.6.871"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.3.1065"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.6.2670"},{"key":"e_1_2_6_42_1","first-page":"201","article-title":"Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells","volume":"46","author":"Fishman MP","year":"2002","journal-title":"Int J Dev Biol"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90611-S"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.7.3853"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1995.1275"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0359"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109244200"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.12.6250"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1988.tb09581.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1607"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(99)01957-5"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.846001"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0959"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(02)00336-2"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.10.2447"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.062041099"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00326-9"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.1.110"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/12674"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.4.1393-1403.2001"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.11.1705"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.22.4905"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5373.91"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200203074"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.11.2317"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.26.12999"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074560"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg840"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012597951-1\/50019-6"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1297-384"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.9.3292-3307.2000"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90029-X"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107124200"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06448.x"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.24.3136"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110495200"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10208"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.12.4445-4454.2000"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00115-5"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/377355a0"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf649"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.31.18749"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.2.163"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/71657"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/371606a0"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.10.2367"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.8819"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng959"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-169x.2002.00623.x"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.4.503"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.9.1987"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3548"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.21.4243"},{"key":"e_1_2_6_94_1","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1101\/gad.14.15.1866","article-title":"Activin receptor patterning of foregut organogenesis","volume":"14","author":"Kim SK","year":"2000","journal-title":"Genes Dev"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng860"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(99)80077-7"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm867"},{"key":"e_1_2_6_98_1","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1242\/dev.128.8.1467","article-title":"The winged\u2010helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos","volume":"128","author":"Kos R","year":"2001","journal-title":"Development"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.9.723"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.23.3752"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250100016"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.14.2.0423"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(00)00317-8"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00378-6"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7754368"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.5.928"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.985002"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.8.2546"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.8454"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.7.10.1275"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0440"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/12669"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.4.464"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-1669-9_1"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(96)80087-1"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.11.2433"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.8.2199"},{"key":"e_1_2_6_118_1","first-page":"922","article-title":"Inductive signals in pancreas development","volume":"11","author":"Melton D","year":"1997","journal-title":"FASEB J"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06363.x"},{"key":"e_1_2_6_120_1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1242\/dev.125.6.1017","article-title":"Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development","volume":"125","author":"Miralles F","year":"1998","journal-title":"Development"},{"key":"e_1_2_6_121_1","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1242\/dev.124.8.1473","article-title":"Mouse serrate\u20101 (jagged\u20101) \u2010 expression in the developing tooth is regulated by epithelial\u2010mesenchymal interactions and fibroblast growth factor\u2010iv","volume":"124","author":"Mitsiadis TA","year":"1997","journal-title":"Development"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10263"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9544"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.14.5256-5260.2000"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.22.3579"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.22.3579"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.1.23"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.8.3560"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-0892-8"},{"key":"e_1_2_6_130_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0472"},{"key":"e_1_2_6_131_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.8.1009"},{"key":"e_1_2_6_132_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.6.1035"},{"key":"e_1_2_6_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-437X(93)90095-7"},{"key":"e_1_2_6_134_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.3.983"},{"key":"e_1_2_6_135_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302684200"},{"key":"e_1_2_6_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb06109.x"},{"key":"e_1_2_6_137_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.12.4228"},{"key":"e_1_2_6_138_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102420200"},{"key":"e_1_2_6_139_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102168499"},{"key":"e_1_2_6_140_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215549804600602"},{"key":"e_1_2_6_141_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010737200"},{"key":"e_1_2_6_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90070-1"},{"key":"e_1_2_6_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10058"},{"key":"e_1_2_6_144_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.8.12.1798"},{"key":"e_1_2_6_145_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.22.10465"},{"key":"e_1_2_6_146_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.1.254"},{"key":"e_1_2_6_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80985-X"},{"key":"e_1_2_6_148_1","first-page":"25","volume-title":"Handbook of physiology, section 7: endocrinology","author":"Pictet R","year":"1972"},{"key":"e_1_2_6_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(72)90083-8"},{"key":"e_1_2_6_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(20000601)259:2<157::AID-AR6>3.0.CO;2-0"},{"key":"e_1_2_6_151_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200105060"},{"key":"e_1_2_6_152_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110747200"},{"key":"e_1_2_6_153_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8744"},{"key":"e_1_2_6_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00209-9"},{"key":"e_1_2_6_155_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.1.125"},{"key":"e_1_2_6_156_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.3.2048"},{"key":"e_1_2_6_157_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106264200"},{"key":"e_1_2_6_158_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00631"},{"key":"e_1_2_6_159_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.13.4702-4713.2002"},{"key":"e_1_2_6_160_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.13.1662"},{"key":"e_1_2_6_161_1","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1242\/dev.127.24.5533","article-title":"Homeobox gene Nkx6. 1 lies downstream of Nkx2.2 in the major pathway of beta\u2010cell formation in the pancreas","volume":"127","author":"Sander M","year":"2000","journal-title":"Development"},{"key":"e_1_2_6_162_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.6.12b.2620"},{"key":"e_1_2_6_163_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.16.3533"},{"key":"e_1_2_6_164_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.1998.00167.x"},{"key":"e_1_2_6_165_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.17.9015"},{"key":"e_1_2_6_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/35046522"},{"key":"e_1_2_6_167_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.062605899"},{"key":"e_1_2_6_168_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.6.1569"},{"key":"e_1_2_6_169_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.12b.2353"},{"key":"e_1_2_6_170_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1996.0060"},{"key":"e_1_2_6_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/386399a0"},{"key":"e_1_2_6_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/387406a0"},{"key":"e_1_2_6_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1097-138"},{"key":"e_1_2_6_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-106"},{"key":"e_1_2_6_175_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad946701"},{"key":"e_1_2_6_176_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.14.5175-5183.2000"},{"key":"e_1_2_6_177_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.12.2213"},{"key":"e_1_2_6_178_1","doi-asserted-by":"crossref","first-page":"12809","DOI":"10.1016\/S0021-9258(18)99948-5","article-title":"An element of the elastase I enhancer is an overlapping bipartite binding site activated by a heteromeric factor","volume":"269","author":"Swift GH","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_6_179_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.24.5319"},{"key":"e_1_2_6_180_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00190586"},{"key":"e_1_2_6_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)80027-1"},{"key":"e_1_2_6_182_1","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1242\/dev.129.6.1477","article-title":"Requirement for downregulation of kreisler during late patterning of the hindbrain","volume":"129","author":"Theil T","year":"2002","journal-title":"Development"},{"key":"e_1_2_6_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90334-V"},{"key":"e_1_2_6_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00273-8"},{"key":"e_1_2_6_185_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.14.3079"},{"key":"e_1_2_6_186_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10119"},{"key":"e_1_2_6_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00412-3"},{"key":"e_1_2_6_188_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20021524"},{"key":"e_1_2_6_189_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.21.12646"},{"key":"e_1_2_6_190_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.10.3.243"},{"key":"e_1_2_6_191_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004981200"},{"key":"e_1_2_6_192_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.20.4345"},{"key":"e_1_2_6_193_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.15.1.393"},{"key":"e_1_2_6_194_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.8.1563"},{"key":"e_1_2_6_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(67)90042-5"},{"key":"e_1_2_6_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(68)90073-0"},{"key":"e_1_2_6_197_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.4.1564"},{"key":"e_1_2_6_198_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00358"},{"key":"e_1_2_6_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(02)00118-1"},{"key":"e_1_2_6_200_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.10.6002"},{"key":"e_1_2_6_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/384458a0"},{"key":"e_1_2_6_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/384455a0"},{"key":"e_1_2_6_203_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2769"},{"key":"e_1_2_6_204_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3667"},{"key":"e_1_2_6_205_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.9.2233"},{"key":"e_1_2_6_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00490-X"},{"key":"e_1_2_6_207_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0473"},{"key":"e_1_2_6_208_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(200002)217:2<180::AID-DVDY5>3.0.CO;2-3"},{"key":"e_1_2_6_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00326-3"},{"key":"e_1_2_6_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00234-3"},{"key":"e_1_2_6_211_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg837"},{"key":"e_1_2_6_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00586-8"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.10460","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.10460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:15:07Z","timestamp":1760382907000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.10460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,10]]},"references-count":211,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1002\/dvdy.10460"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.10460","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,10]]}}}