{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:41:39Z","timestamp":1791024099200,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,3,27]],"date-time":"2001-03-27T00:00:00Z","timestamp":985651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["Br 2053\/1-1"],"award-info":[{"award-number":["Br 2053\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Abstract<\/jats:p><jats:p>Chondromodulin\u2010I (CHM1) was identified recently as an angiogenesis inhibitor in cartilage. It is highly expressed in the avascular zones of cartilage but is absent in the late hypertrophic region, which is invaded by blood vessels during enchondral ossification. Blast searches with the C\u2010terminal part of CHM1 in available databases led to the identification of human and mouse cDNAs encoding a new protein, Tendin, that shares high homology with CHM1. Based on computer predictions, Tendin is a type II transmembrane protein containing a putative proteinase cleavage and two glycosylation sites. Northern assays with mouse RNAs demonstrated strong expression of a 1.5\u2010kb <jats:italic>tendin<\/jats:italic> transcript in the diaphragm, skeletal muscle, and the eye and low levels of expression in all other tissues investigated. In 17.5\u2010day\u2010old mouse embryos, in situ hybridization revealed high levels of <jats:italic>tendin<\/jats:italic> transcript in tendons and ligaments. Additional signals were detected in brain and spinal cord, liver, lung, bowels, thymus, and eye. Cartilage, where CHM1 is found, revealed low levels of <jats:italic>tendin<\/jats:italic> m\u2010RNA. In adult mice, <jats:italic>tendin<\/jats:italic> is expressed in neurons of all brain regions and the spinal cord. The <jats:italic>tendin<\/jats:italic> gene is localized in the human Xq22 region, to which several human diseases have been mapped. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.1126","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T18:08:54Z","timestamp":1030298934000},"page":"72-80","source":"Crossref","is-referenced-by-count":103,"title":["A novel gene, <i>tendin<\/i>, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin\u2010I"],"prefix":"10.1002","volume":"221","author":[{"given":"Oliver","family":"Brandau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfons","family":"Meindl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"F\u00e4ssler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Asz\u00f3di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,3,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330519"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1247\/csf.25.73"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.1.217"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90129-M"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.10.e46"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(00)96003-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01299.x"},{"key":"e_1_2_6_10_1","first-page":"156","article-title":"Single\u2010step method of RNA isolation by acid guanidinium thiocyanate\u2010phenol\u2010chloroform extraction","volume":"162","author":"Chomcynski P","year":"1987","journal-title":"Anal Biochem"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/9460"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)01201-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670000339"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(91)91660-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.51.32419"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)01151-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7820"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050250"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5415"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"9628","DOI":"10.1016\/S0021-9258(19)38715-0","article-title":"An 18\u2010kDa glycoprotein from bovine nasal cartilage: isolation and primary structure of small, cartilage\u2010derived glycoprotein","volume":"265","author":"Neame PJ","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_6_21_1","first-page":"39","article-title":"Spatiotemporal pattern of the mouse chondromodulin\u2010I gene expression and its regulatory role in vascular invasion into cartilage during endochondral bone formation","volume":"43","author":"Shukunami C","year":"1999","journal-title":"Int J Dev Biol"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.1126","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.1126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T23:02:22Z","timestamp":1760396542000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.1126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,27]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["10.1002\/dvdy.1126"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.1126","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3,27]]}}}