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Voltage\u2010gated potassium channels were traditionally viewed, mainly by electrophysiologists, as regulators of the electrical activity of the plasma membrane in excitable cells, a role that is performed by transmembrane protein domains of \u03b1\u2010subunits that form the electric pore. Genetic studies revealed a role for this region of \u03b1\u2010subunits of voltage\u2010gated potassium channels in human neurodevelopmental disorders, such as epileptic encephalopathy. The N\u2010 and C\u2010terminal domains of \u03b1\u2010subunits interact to form the cytoplasmic subunit of heterotetrameric potassium channels that regulate electric pores. Subsequent animal studies revealed the developmental functions of Kcnb1\u2010containing voltage\u2010gated potassium channels and illustrated their role during brain development and reproduction. 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