{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:23:13Z","timestamp":1791325393107,"version":"4.3.1"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,10,22]],"date-time":"2001-10-22T00:00:00Z","timestamp":1003708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The paired box containing transcription factor <jats:italic>Pax3<\/jats:italic> is a crucial regulator of dermomyotome and muscle development. However, the allelic series of <jats:italic>Pax3\/Splotch<\/jats:italic> mutants also displays characteristic vertebral column malformations, which do not result from defective dorsoventral somite pattern. Rather, vertebral column and sclerotomal phenotypes are reminiscent of the phenotypes observed in the segmentation\/somitogenesis mutants <jats:italic>rachiterata<\/jats:italic> and <jats:italic>pudgy<\/jats:italic>. Moreover, rostrocaudal somite pattern and somitic boundaries are disturbed in <jats:italic>Splotch<\/jats:italic> as monitored by the expression of <jats:italic>Uncx4.1<\/jats:italic> and <jats:italic>Lunatic fringe<\/jats:italic>. Alterations in <jats:italic>EphA4<\/jats:italic>, <jats:italic>Dll1<\/jats:italic>, and <jats:italic>Uncx4.1<\/jats:italic> expression are evident already in the condensing paraxial mesoderm, correlating with the first phase of <jats:italic>Pax3<\/jats:italic> expression before and during somite formation. This finding suggests an early function of <jats:italic>Pax3<\/jats:italic> during the formation of epithelial somites. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.1211","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T17:17:12Z","timestamp":1030295832000},"page":"506-521","source":"Crossref","is-referenced-by-count":67,"title":["Early mesodermal phenotypes in <i>splotch<\/i> suggest a role for <i>Pax3<\/i> in the formation of epithelial somites"],"prefix":"10.1002","volume":"222","author":[{"given":"Frank R.","family":"Schubert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mansouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja 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