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In addition to bundling actin, Fascin has several actin\u2010independent roles; how these other functions contribute to cell migration remains unclear. Border cell migration during\n                      <jats:italic>Drosophila<\/jats:italic>\n                      oogenesis provides an excellent model to study Fascin's various roles during invasive, collective cell migration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      On\u2010time border cell migration during Stage 9 requires Fascin (\n                      <jats:italic>Drosophila<\/jats:italic>\n                      Singed). Fascin functions not only within the migrating border cells, but also within the nurse cells, the substrate for this migration. Fascin genetically interacts with the actin elongation factor Enabled to promote on\u2010time Stage 9 migration and overexpression of Enabled suppresses the defects seen with loss of Fascin. Loss of Fascin results in increased, shorter and mislocalized protrusions during migration. Additionally, loss of Fascin inhibits border cell delamination and increases E\u2010Cadherin (\n                      <jats:italic>Drosophila<\/jats:italic>\n                      Shotgun) adhesions on both the border cells and nurse cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Overall, Fascin promotes on\u2010time border cell migration during Stage 9 and contributes to multiple aspects of this invasive, collective cell migration, including both protrusion dynamics and delamination. These findings have implications beyond\n                      <jats:italic>Drosophila<\/jats:italic>\n                      , as border cell migration has emerged as a model to study mechanisms mediating cancer metastasis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dvdy.186","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T15:26:29Z","timestamp":1588260389000},"page":"961-982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Fascin regulates protrusions and delamination to mediate invasive, collective cell migration in vivo"],"prefix":"10.1002","volume":"249","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4522-1910","authenticated-orcid":false,"given":"Maureen C.","family":"Lamb","sequence":"first","affiliation":[{"name":"Anatomy and Cell Biology University of Iowa Carver College of Medicine  Iowa City Iowa 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