{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:45:36Z","timestamp":1791114336485,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,8,5]],"date-time":"2004-08-05T00:00:00Z","timestamp":1091664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Snail family of zinc\u2010finger transcriptional repressors is essential for morphogenetic cell movements, mesoderm formation, and neurogenesis during embryonic development. These proteins also control cell cycle, cell death, and cancer progression. In <jats:italic>Drosophila<\/jats:italic>, three members of this protein family, Snail, Escargot, and Worniu, have essential but redundant functions in asymmetric cell division of neuroblasts. In addition, Snail is critical for early mesoderm formation and Escargot is required for maintaining diploidy in wing imaginal disc cells. In this report, we demonstrate that Worniu plays a role in brain development. We show that alleles of the <jats:italic>l(2)35Da<\/jats:italic> complementation group are mutants of <jats:italic>worniu<\/jats:italic>. The developing larvae of these mutant alleles fail to shorten their brainstems. The brain phenotype, as well as the lethality, of these mutants can be rescued by <jats:italic>worniu<\/jats:italic> transgenes. Moreover, RNAi experiments targeting the <jats:italic>worniu<\/jats:italic> transcript show the same nonshortening phenotype in larval brains. <jats:italic>worniu<\/jats:italic> is expressed in the neuroblasts of brain hemispheres and ventral ganglions. The results suggest that the loss of Worniu function within the neuroblasts ultimately causes the larval brainstem to fail to go through shortening during development. Developmental Dynamics 231:379\u2013386, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.20130","type":"journal-article","created":{"date-parts":[[2004,8,9]],"date-time":"2004-08-09T16:58:00Z","timestamp":1092070680000},"page":"379-386","source":"Crossref","is-referenced-by-count":25,"title":["Worniu, a Snail family zinc\u2010finger protein, is required for brain development in <i>Drosophila<\/i>"],"prefix":"10.1002","volume":"231","author":[{"given":"Shovon I.","family":"Ashraf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atish","family":"Ganguly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Roote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. 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