{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:07:37Z","timestamp":1772118457513,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,21]],"date-time":"2004-10-21T00:00:00Z","timestamp":1098316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Most muscle originates from the myotomal compartment of the somites, paired structures flanking the neural tube. Whereas vertebrate embryos show molecular and morphological asymmetry about the left\u2013right body axis, somitic myogenesis is thought to occur symmetrically. Here, we provide the first evidence that myotome pairs are transiently left\u2013right asymmetric, with higher expression of \u03b1\u2010\n                    <jats:italic>skeletal actin<\/jats:italic>\n                    and\n                    <jats:italic>myosin light chain 3F<\/jats:italic>\n                    (\n                    <jats:italic>MLC3F<\/jats:italic>\n                    ) on the left side between embryonic day 9.5\u201310.25. In\n                    <jats:italic>iv<\/jats:italic>\n                    mutants with\n                    <jats:italic>situs inversus<\/jats:italic>\n                    , the asymmetric expression of \u03b1\u2010\n                    <jats:italic>skeletal actin<\/jats:italic>\n                    and\n                    <jats:italic>MLC3F<\/jats:italic>\n                    was inverted, showing that this process is regulated by global left\u2013right axis cues, initiated before gastrulation. However, although left\u2013sided identity is later maintained by\n                    <jats:italic>Pitx2<\/jats:italic>\n                    genes, we found that\n                    <jats:italic>Pitx2c<\/jats:italic>\n                    null embryos have normal left\u2010biased expression of \u03b1\u2010\n                    <jats:italic>skeletal actin<\/jats:italic>\n                    and\n                    <jats:italic>MLC3F<\/jats:italic>\n                    . Myotome asymmetry, therefore, is downstream of the\n                    <jats:italic>iv<\/jats:italic>\n                    mutation but upstream of, or unrelated to, the\n                    <jats:italic>Pitx2c<\/jats:italic>\n                    pathway. Developmental Dynamics 231:795\u2013800, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/dvdy.20176","type":"journal-article","created":{"date-parts":[[2004,10,22]],"date-time":"2004-10-22T06:28:02Z","timestamp":1098426482000},"page":"795-800","source":"Crossref","is-referenced-by-count":15,"title":["Mouse myotomes pairs exhibit left\u2013right asymmetric expression of\n                    <i>MLC3F<\/i>\n                    and \u03b1\u2010\n                    <i>skeletal actin<\/i>"],"prefix":"10.1002","volume":"231","author":[{"given":"Jon P.","family":"Golding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence A.","family":"Partridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R.","family":"Beauchamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Gassmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter 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