{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:22:02Z","timestamp":1777454522820,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,12,21]],"date-time":"2004-12-21T00:00:00Z","timestamp":1103587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Flamingo is one of a core group of proteins that regulate planar cell polarity of epithelial structures within the <jats:italic>Drosophila<\/jats:italic> embryo while their vertebrate counterparts have been implicated in the coordination of convergent extension movements during gastrulation and in neural tube closure, suggesting that planar polarity mechanisms also function in these processes. Failure of neural tube closure is one of the most common human birth defects, and a murine <jats:italic>flamingo<\/jats:italic> (<jats:italic>fmi<\/jats:italic>) homologue, <jats:italic>Celsr1<\/jats:italic>\/<jats:italic>fmi<\/jats:italic>\u2010<jats:italic>1<\/jats:italic>, was identified as the defective gene in two mouse mutants exhibiting failure of closure 1 of the neural tube. This failure resulted in craniorachischisis in which the neural tube is open from the midbrain posteriorly. The avian embryo provides a tractable system to study neural tube closure. We have identified a chick <jats:italic>Celsr1<\/jats:italic>\/<jats:italic>fmi<\/jats:italic>\u2010<jats:italic>1<\/jats:italic> orthologue, <jats:italic>c<\/jats:italic>\u2010<jats:italic>fmi1<\/jats:italic> and provide the first study of expression of an avian <jats:italic>flamingo<\/jats:italic> gene. We show that expression is highly dynamic in the early embryo and that <jats:italic>c<\/jats:italic>\u2010<jats:italic>fmi1<\/jats:italic> transcripts become enriched within the avian neural epithelium at the initiation of neural tube closure, suggesting a conserved function for Flamingo proteins in this process. Our data also suggest a role for <jats:italic>c<\/jats:italic>\u2010<jats:italic>fmi1<\/jats:italic> in myotome development. Developmental Dynamics 232:408\u2013413, 2005. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.20228","type":"journal-article","created":{"date-parts":[[2004,12,21]],"date-time":"2004-12-21T18:33:26Z","timestamp":1103654006000},"page":"408-413","source":"Crossref","is-referenced-by-count":25,"title":["Expression of the <i>Celsr<\/i>\/<i>flamingo<\/i> homologue, <i>c<\/i>\u2010<i>fmi1<\/i>, in the early avian embryo indicates a conserved role in neural tube closure and additional roles in asymmetry and somitogenesis"],"prefix":"10.1002","volume":"232","author":[{"given":"Caroline J.","family":"Formstone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivor","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.23.5421"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.1144"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1181"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00374-9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00515-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00088-X"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(98)00153-1"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050880104"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1084952102001003"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.11.2675"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051277"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950190406"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81143-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001550404"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80046-X"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.20228","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.20228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:07:04Z","timestamp":1760346424000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.20228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,21]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["10.1002\/dvdy.20228"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.20228","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,21]]}}}