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We show that, during development, ROL and retinyl ester levels are decreased in CRBP type 1 (CRBP1) \u2010deficient embryos and fetuses by 50% and 80%, respectively. The steady state level of retinoic acid (RA) is also decreased but to a lesser extent. However, CRBP1\u2010null fetuses do not exhibit the abnormalities characteristic of a vitamin A\u2010deficiency syndrome. Neither CRBP1 deficiency alters the expression patterns of RA\u2010responding genes during development, nor does CRBP1 availability modify the expression of an RA\u2010dependent gene in primary embryonic fibroblasts treated with ROL. Therefore, CRBP1 is required in prenatal life to maintain normal amounts of ROL and to ensure its efficient storage but seems of secondary importance for RA synthesis, at least under conditions of maternal vitamin A sufficiency. Developmental Dynamics 233:167\u2013176, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.20313","type":"journal-article","created":{"date-parts":[[2005,3,11]],"date-time":"2005-03-11T17:16:33Z","timestamp":1110561393000},"page":"167-176","source":"Crossref","is-referenced-by-count":40,"title":["Contribution of cellular retinol\u2010binding protein type 1 to retinol metabolism during mouse development"],"prefix":"10.1002","volume":"233","author":[{"given":"Nicolas","family":"Matt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten K.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Dup\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Dennefeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Nau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Chambon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert B.","family":"Ghyselinck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,3,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(93)25052-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.16.9526"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(97)00167-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1991.71.4.951"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)54565-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.10.5610"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1995.1226"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.9.8801176"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb07102.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1242\/dev.110.4.1133","article-title":"Retinoic acid receptors and cellular retinoid binding proteins. 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