{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:01:34Z","timestamp":1760403694516,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,3,11]],"date-time":"2005-03-11T00:00:00Z","timestamp":1110499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Insulin\u2010like growth factor\u2010II (IGF\u2010II) deficiency occurs when a conceptus inherits an inactive gene from the father (<jats:italic>Igf2m+\/p\u2212<\/jats:italic>): fetal wet weight is reduced to 60% of wild\u2010type, with the decline starting at E11. The umbilical cord vessels of mutant and wild\u2010type were compared. At E8.0\u2013E8.5, the timing of somite formation and chorioallantoic fusion was not altered. At E14.5\u2013E16.5, the left umbilical artery degenerated approximately 1 day later in <jats:italic>Igf2m+\/p\u2212<\/jats:italic> conceptuses when compared with the wild\u2010type. In the common umbilical artery at E15.5, muscle volume was reduced by one third in IGF\u2010II deficiency. Treating the umbilical arteries as ideal tubes, the values of radius<jats:sup>4<\/jats:sup>\/length suggest that blood flow through the placenta may be reduced by more than half in the <jats:italic>Igf2m+\/p\u2212<\/jats:italic> conceptuses. Developmental Dynamics 233:88\u201394, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.20320","type":"journal-article","created":{"date-parts":[[2005,3,11]],"date-time":"2005-03-11T17:46:38Z","timestamp":1110563198000},"page":"88-94","source":"Crossref","is-referenced-by-count":4,"title":["Delayed and disturbed morphogenesis of the umbilical blood vessels in insulin\u2010like growth factor\u2010II deficient conceptuses (<i>Igf2m+\/p\u2212<\/i>)"],"prefix":"10.1002","volume":"233","author":[{"given":"Amatul 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