{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T18:20:23Z","timestamp":1780856423360,"version":"3.54.1"},"reference-count":125,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,3,18]],"date-time":"2005-03-18T00:00:00Z","timestamp":1111104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The epidermal growth factor receptor (EGFR) regulates multiple patterning events in <jats:italic>Drosophila<\/jats:italic> limb development, but its role in vertebrate limb morphogenesis has received little attention. The EGFR and several of its ligands are expressed in developing vertebrate limbs in manners consistent with potential patterning roles. To gain insight into functions of EGFR signaling in vertebrate limb development, we expressed a constitutively active EGFR in developing chick limbs in ovo. Expression of activated EGFR causes pre\u2010 and postaxial polydactyly, including mirror\u2010image\u2013type digit duplication, likely due to induction of ectopic expression and\/or modulation of genes involved in anterior\u2013posterior (AP) patterning such as <jats:italic>Sonic hedgehog<\/jats:italic> (<jats:italic>Shh<\/jats:italic>), <jats:italic>dHand, Patched<\/jats:italic> (<jats:italic>Ptc<\/jats:italic>), <jats:italic>Gli3, Hoxd13, Hoxd11, bone morphogenetic protein 2<\/jats:italic> (<jats:italic>Bmp2<\/jats:italic>), <jats:italic>Gremlin<\/jats:italic>, and <jats:italic>FGF4<\/jats:italic>. Activation of EGFR signaling dorsalizes the limb and alters expression of the dorsal\u2013ventral (DV) patterning genes <jats:italic>Wnt7a, Lmx<\/jats:italic>, and <jats:italic>En1<\/jats:italic>. Ectopic and\/or extended <jats:italic>FGF8<\/jats:italic> expressing apical ectodermal ridges (AERs) are also seen. Interdigital regression is inhibited and the digits fail to separate, leading to syndactyly, likely due to antiapoptotic and pro\u2010proliferative effects of activated EGFR signaling on limb mesoderm, and\/or attenuation of interdigital <jats:italic>Bmp4<\/jats:italic> expression. These findings suggest potential roles for EGFR signaling in AP and DV patterning, AER formation, and cell survival during limb morphogenesis. Developmental Dynamics 233:288\u2013300, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.20353","type":"journal-article","created":{"date-parts":[[2005,3,19]],"date-time":"2005-03-19T07:20:31Z","timestamp":1111216831000},"page":"288-300","source":"Crossref","is-referenced-by-count":22,"title":["Studies on epidermal growth factor receptor signaling in vertebrate limb patterning"],"prefix":"10.1002","volume":"233","author":[{"given":"Minoru","family":"Omi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nita J.","family":"Maihle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline N.","family":"Dealy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,3,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/08977190410001700998"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1242\/dev.128.22.4449","article-title":"BMPR\u2010IA signaling is required for the formation of the apical ectodermal ridge and dorsal\u2010ventral patterning of the limb","volume":"128","author":"Ahn K","year":"2001","journal-title":"Development"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00008239"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1242\/dev.124.22.4547","article-title":"Dorso\u2010ventral ectodermal compartments and origin of the apical ectodermal ridge in developing chick limb","volume":"124","author":"Altabef M","year":"1997","journal-title":"Development"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.13.7331"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1044903"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(02)00096-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.06.012"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00971"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.17.1.87"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/35065000"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00448-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1242\/dev.127.11.2461","article-title":"The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development","volume":"127","author":"Charite J","year":"2000","journal-title":"Development"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051267"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-010X(19981215)282:6<691::AID-JEZ5>3.0.CO;2-S"},{"key":"e_1_2_6_17_1","first-page":"927","article-title":"Wnt signaling during limb development","volume":"46","author":"Church VL","year":"2002","journal-title":"Int J Dev Biol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01115"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.embor735"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/genetics\/123.4.771","article-title":"Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene","volume":"122","author":"Clifford RT","year":"1989","journal-title":"Genetics"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(91)90051-7"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80999-X"},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1242\/dev.129.18.4261","article-title":"Connecting Hh, Dpp and EGF signaling in patterning of the Drosophila wing; the pivotal role of collier\/knot in the AP organizer","volume":"129","author":"Crozatier M","year":"2002","journal-title":"Development"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(99)01774-6"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5478.438"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/08977190290022185"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002020107"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0163"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(93)90034-U"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8988"},{"key":"e_1_2_6_31_1","first-page":"389","article-title":"The capacity of the flank somatic mesoderm of early bird embryos to participate in limb development","volume":"18","author":"Douailly D","year":"1972","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_6_32_1","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1242\/dev.127.7.1337","article-title":"A model for anteroposterior patterning of the vertebrate limb based on sequential long\u2010 and short\u2010range Shh signalling and BMP signalling","volume":"127","author":"Drossopoulou G","year":"2000","journal-title":"Development"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00581.2001"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00381-6"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.10.2133"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8880"},{"key":"e_1_2_6_37_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1242\/dev.120.1.209","article-title":"Bone morphogenetic protein and a signaling pathway that controls patterning in the developing chick limb","volume":"120","author":"Francis PH","year":"1994","journal-title":"Development"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072311"},{"key":"e_1_2_6_39_1","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1242\/dev.122.8.2349","article-title":"Role of TGF\u2010\u03b2s and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod","volume":"122","author":"Ganan Y","year":"1996","journal-title":"Development"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.2741\/grant"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204192"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0752"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(99)80024-6"},{"key":"e_1_2_6_44_1","first-page":"1509","article-title":"Epidermal growth factor\u2010induced activation of the insulin\u2010like growth factor receptor in rat hepatocytes","volume":"36","author":"Hallak H","year":"2002","journal-title":"Hepatology"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.1.155"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80067-2"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.09.173"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg264"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(02)00098-8"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00285-9"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb989"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5367.1274"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1178"},{"key":"e_1_2_6_54_1","first-page":"457","article-title":"Role inducteur du mesoderme dans la differentiation precoce du bourgeon de membre chez l'embryon de poulet","volume":"8","author":"Kieny M","year":"1960","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.11.1377"},{"key":"e_1_2_6_56_1","first-page":"75","article-title":"In vitro studies on the morphogenesis and differentiation of the mesoderm subjacent to the apical ectodermal ridge of the embryonic chick limb bud","volume":"50","author":"Kosher RA","year":"1979","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/39348"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90030-2"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/386366a0"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.8.5.1970"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01033"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.1020130505"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.6.1137"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90228-I"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90227-H"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.4.1225"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.13.3077"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-169X.2002.00647.x"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.23.5515"},{"key":"e_1_2_6_70_1","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1242\/dev.124.8.1453","article-title":"The dorsoventral polarity of the presumptive limb is determined by signals produced by the somites and by the lateral somatopleure","volume":"124","author":"Michaud JL","year":"1997","journal-title":"Development"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/376337a0"},{"key":"e_1_2_6_72_1","series-title":"Methods in cell biology","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0091-679X(08)60629-9","author":"Morgan BA","year":"1996"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2004.04267.x"},{"key":"e_1_2_6_74_1","first-page":"877","article-title":"Interplay between the molecular signals that control vertebrate limb development","volume":"46","author":"Niswander L","year":"2002","journal-title":"Int J Dev Biol"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/371609a0"},{"key":"e_1_2_6_76_1","first-page":"795","article-title":"Convergence of the BMP and EGF signaling pathways on Smad1 in the regulation of chondrogenesis","volume":"43","author":"Nonaka K","year":"1999","journal-title":"Int J Dev Biol"},{"key":"e_1_2_6_77_1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2741\/Normano","article-title":"The role of EGF\u2010related peptides in tumor growth","volume":"6","author":"Normanno N","year":"2001","journal-title":"Front Biosci"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.11.2235"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.9.5042"},{"key":"e_1_2_6_80_1","first-page":"381","article-title":"Role of chondrogenic tissue in programmed cell death and BMP expression in chick limb buds","volume":"44","author":"Omi M","year":"2000","journal-title":"Int J Dev Biol"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0804"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2003.00138.x"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.18.7164"},{"key":"e_1_2_6_84_1","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1242\/dev.128.22.4463","article-title":"BMP controls proximodistal outgrowth via induction of the apical ectodermal ridge and dorsoventral patterning of the vertebrate limb","volume":"128","author":"Pizette S","year":"2001","journal-title":"Development"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0080011"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20007"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90626-2"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90103-5"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/386360a0"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/21.5.1316"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001930112"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(82)90241-X"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200307137"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.1108"},{"key":"e_1_2_6_95_1","first-page":"1","volume-title":"Vertebrate limb and somite morphogenesis","author":"Saunders JW","year":"1977"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(74)90257-7"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00260.2001"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7618085"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(96)00643-0"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.263003"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5244.1995"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100602200"},{"key":"e_1_2_6_103_1","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1242\/dev.127.18.4011","article-title":"Distribution of polarising activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly","volume":"127","author":"Tanaka M","year":"2000","journal-title":"Development"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(02)00112-2"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075620"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.219202"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00352.2004"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7618084"},{"key":"e_1_2_6_109_1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1534-5807(03)00095-9","article-title":"Patterning systems\u2010from one end o f the limb to the other","volume":"4","author":"Tickle C","year":"2003","journal-title":"Dev Cell"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.25478"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.827000"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80678-9"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.01.016"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2003.134"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7771"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/35052073"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.12.2573"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.25.13695"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096049"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.6.1369"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.6.1357"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9637"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.17.2191"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/44157"},{"key":"e_1_2_6_125_1","first-page":"871","article-title":"Programmed cell death in the developing limb","volume":"46","author":"Zuzarte\u2010Lu\u00eds V","year":"2002","journal-title":"Int J Dev Biol"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4831-9948-1.50011-5"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.20353","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.20353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T22:02:03Z","timestamp":1760392923000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.20353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,18]]},"references-count":125,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1002\/dvdy.20353"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.20353","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,18]]}}}