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Fusion then progresses bi\u2010directionally along the longitudinal axis in both cranial and caudal directions. Using in vivo labeling, we demonstrate that cells along the ventral fusion line are highly motile, crossing future primitive segments. We found that mesoderm cells migrated cephalically from the unfused tips of the anterior\/cephalic wings into the head mesenchyme in the region that has been called the secondary heart field. Perturbing the anterior\/cranial fusion results in formation of a bi\u2010conal heart. A theoretical role of the ventral fusion line acting as a \u201cheart organizer\u201d and its role in cardia bifida is discussed. Developmental Dynamics 235:191\u2013202, 2006. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.20601","type":"journal-article","created":{"date-parts":[[2005,10,26]],"date-time":"2005-10-26T15:16:47Z","timestamp":1130339807000},"page":"191-202","source":"Crossref","is-referenced-by-count":46,"title":["Bidirectional fusion of the heart\u2010forming fields in the developing chick embryo"],"prefix":"10.1002","volume":"235","author":[{"given":"R.A.","family":"Moreno\u2010Rodriguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.L.","family":"Krug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Villavicencio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.H.","family":"Mjaatvedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.R.","family":"Markwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.05.016"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10148"},{"key":"e_1_2_5_4_1","first-page":"1","article-title":"Experimental study of the formation of the heart tube in the chick embryo","volume":"33","author":"Arg\u00fcello C","year":"1975","journal-title":"J Embryol Exp Morph"},{"key":"e_1_2_5_5_1","volume-title":"The atlas of chick development","author":"Bellairs R","year":"1998"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01046587"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00363-0"},{"key":"e_1_2_5_8_1","first-page":"623","article-title":"Experimental study of the formation of the bulboventricular loop in the chick","volume":"27","author":"Castro\u2010Quezada A","year":"1972","journal-title":"J Embryol Exp Morphol."},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(200006)218:2<316::AID-DVDY6>3.0.CO;2-8"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1242\/dev.128.20.3937","article-title":"Cell autonomous commitment to an endodermal fate and behaviour by activation of Nodal signalling","volume":"128","author":"David NB","year":"2001","journal-title":"Development"},{"key":"e_1_2_5_11_1","first-page":"245","article-title":"Development of the human heart from its first appearance to the stage found in embryos of twenty paired somites","volume":"19","author":"Davis CL","year":"1927","journal-title":"Carnegie Contrib Embryol"},{"key":"e_1_2_5_12_1","first-page":"121","article-title":"The primitive cardiac regions in the straight tube heart (Stage 9\u2010) and their anatomical expression in the mature heart: an experimental study in the chick embryo","volume":"165","author":"De la Cruz MV","year":"1989","journal-title":"J Anat"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199704)247:4<512::AID-AR10>3.0.CO;2-S"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951101000932"},{"key":"e_1_2_5_15_1","first-page":"461","article-title":"The development of the myocardium and endocardium in mouse embryos. 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