{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:06:38Z","timestamp":1791385598066,"version":"4.3.3"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ultimobranchial body (UBB) is an outpocketing of the fourth pharyngeal pouch that fuses with the thyroid diverticulum, giving rise to calcitonin\u2010producing C\u2010cells. In this study, we demonstrate that the UBB is composed of two types of cells: one expressing T\/ebp\/Nkx2.1 and the other expressing p63. The former cell type, accounting for a majority of the UBB, requires T\/ebp\/Nkx2.1 for their survival. In contrast, the p63\u2010positive cells, even in the absence of T\/ebp\/Nkx2.1 expression, can proliferate and give rise to a vesicular structure that is lined by a monolayer of p63\u2010negative cells, surrounded by a cluster and\/or single layer of p63\u2010positive cells, displaying the basal\/stem cell phenotype. T\/ebp\/Nkx2.1 haploinsufficiency causes abnormal fusion of the UBB with the thyroid diverticulum, which stays as a cluster of C\u2010cells around the vesicular structure, similar to the one observed in mice null for T\/ebp\/Nkx2.1 expression. These results demonstrate that T\/ebp\/Nkx2.1 plays a role in the survival of UBB cells, their dissemination into the thyroid diverticulum, and the formation of UBB\u2010derived vesicular structure. Developmental Dynamics 235:1300\u20131309, 2006. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.20655","type":"journal-article","created":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T17:53:05Z","timestamp":1133977985000},"page":"1300-1309","source":"Crossref","is-referenced-by-count":59,"title":["Origin of the ultimobranchial body cyst: T\/ebp\/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the 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