{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:44:51Z","timestamp":1790858691993,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,5]],"date-time":"2006-01-05T00:00:00Z","timestamp":1136419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mutations in the zinc finger transcription factor <jats:italic>ZIC3<\/jats:italic> are associated with human left\u2010right patterning abnormalities (X\u2010linked heterotaxy, HTX1, MIM 306955), and mice null for <jats:italic>Zic3<\/jats:italic> show a similar phenotype. However, the developmental function of Zic3 is largely unknown and its expression in early embryonic development suggests a role prior to organ formation. The current study of <jats:italic>Zic3<\/jats:italic> null mice identifies a novel function for Zic3 in the gastrula\u2010stage embryo. Analysis of Zic3 function at early embryonic stages shows that it ensures the fidelity of embryonic patterning, including patterning of the anterior visceral endoderm, the initiation of gastrulation, and positioning of the primitive streak. At later stages, deficiency of Zic3 results in abnormal mesoderm allocation. These results indicate a requirement for Zic3 during early embryogenesis prior to cardiac and visceral organ patterning. Developmental Dynamics 235:776\u2013785, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.20668","type":"journal-article","created":{"date-parts":[[2006,1,5]],"date-time":"2006-01-05T18:21:51Z","timestamp":1136485311000},"page":"776-785","source":"Crossref","is-referenced-by-count":50,"title":["<i>Zic3<\/i> is critical for early embryonic patterning during gastrulation"],"prefix":"10.1002","volume":"235","author":[{"given":"Stephanie M.","family":"Ware","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine G.","family":"Harutyunyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Belmont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.2.1043"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(98)01499-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80560-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(97)00125-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00318-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/35082103"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.20.4395"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.14.2829"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.7.1919"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.2.439"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/35042039"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/27215"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.118.4.1255"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.16.3015"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modgep.2004.03.003"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7809630"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1197-305"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.1221"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg732"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1242\/dev.113.3.913","article-title":"Expression pattern of the Brachyury gene in whole mount Twis\/Twis mutant embryos","volume":"113","author":"Hermann B","year":"1991","journal-title":"Development"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.11.2723"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10098"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0289"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-169x.2002.00624.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000773200"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.22.4855"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.10.1831"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00208-2"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(01)00018-1"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200526"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80331-7"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(01)00006-5"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004430200"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00225"},{"key":"e_1_2_6_36_1","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1242\/dev.126.20.4499","article-title":"HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior\u2010posterior polarity in the mouse embryo","volume":"126","author":"Perea\u2010Gomez A","year":"1999","journal-title":"Development"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.5.753"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00321-0"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/17820"},{"key":"e_1_2_6_40_1","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1242\/dev.124.15.2997","article-title":"Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm","volume":"124","author":"Popperl H","year":"1997","journal-title":"Development"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.9.2293"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/345686a0"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/35003601"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.118.1.47"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/344435a0"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/374425a0"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.14.1834"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.2.174"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00156"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1086\/380998"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00256-3"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80324-4"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.20668","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.20668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:45:48Z","timestamp":1760366748000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.20668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,5]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1002\/dvdy.20668"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.20668","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,5]]}}}