{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:00:03Z","timestamp":1791327603232,"version":"4.3.1"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,3,13]],"date-time":"2006-03-13T00:00:00Z","timestamp":1142208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    5\u2032\u2010TG\u20103\u2032\u2010interacting factor (TGIF) is an atypical homeodomain protein. In vitro studies have shown that TGIF can repress transcription mediated by either of two signaling pathways: TGF\u2010\u03b2 and retinoic acid signaling. Mutations in\n                    <jats:italic>TGIF<\/jats:italic>\n                    have been detected in patients with holoprosencephaly (HPE), a severe brain malformation associated with mental retardation. Thus, TGIF must play an essential role in nervous system development. However, the precise function of TGIF during vertebrate neural development is unknown. To investigate the in vivo role of TGIF, we overexpressed\n                    <jats:italic>TGIF<\/jats:italic>\n                    in the developing chick neural tube. Overexpressed\n                    <jats:italic>TGIF<\/jats:italic>\n                    decreased expression of specific genes expressed in dorsally restricted domains of the neural tube, including\n                    <jats:italic>Cath1<\/jats:italic>\n                    ,\n                    <jats:italic>Msx2<\/jats:italic>\n                    ,\n                    <jats:italic>Pax6<\/jats:italic>\n                    , and\n                    <jats:italic>Wnt1<\/jats:italic>\n                    . In contrast, the expression of other transcription factors, including those necessary for ventral fate such as\n                    <jats:italic>Nkx2.2<\/jats:italic>\n                    , was not affected. Furthermore, a missense mutation in\n                    <jats:italic>TGIF<\/jats:italic>\n                    identified in an HPE patient disrupted the activity of TGIF. In addition, the related protein TGIF2 did not demonstrate the same activity as TGIF. Our data suggest that TGIF plays an important role in regulating the expression of genes expressed in specific dorsal\u2013ventral domains during neural development. Developmental Dynamics 235:1482\u20131490, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/dvdy.20725","type":"journal-article","created":{"date-parts":[[2006,3,13]],"date-time":"2006-03-13T14:16:47Z","timestamp":1142259407000},"page":"1482-1490","source":"Crossref","is-referenced-by-count":31,"title":["<i>TGIF<\/i>\n                    , a gene associated with human brain defects, regulates neuronal development"],"prefix":"10.1002","volume":"235","author":[{"given":"Jessica L.","family":"Knepper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison C.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-002-0862-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00513"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00609"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.52.31178"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.21.4173"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00172-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/2484"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1073"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.202"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/383407a0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10258"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960823)64:3<465::AID-AJMG4>3.0.CO;2-O"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-002-0709-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80323-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.2439"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9311"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00367-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/76074"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.23.3106"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050880104"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3449"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/35049541"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2005.01.010"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.1.60"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198510033131401"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00994"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00121-5"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420160304"},{"key":"e_1_2_6_30_1","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1242\/dev.128.20.4069","article-title":"Role of Pax3\/7 in the tectum regionalization","volume":"128","author":"Matsunaga E","year":"2001","journal-title":"Development"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000416200"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103377200"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1086\/344412"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00348-2"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-002-0695-5"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00084-8"},{"key":"e_1_2_6_37_1","first-page":"6203","volume-title":"The metabolic & molecular bases of inherited disease","author":"Muenke M","year":"2001"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2003.08.006"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.894701"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2004.04.019"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1196-357"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.11.1847"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2235734100"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.16.3252"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.9.3639-3647.2005"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420510605"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10066"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.10.2459"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/9718"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00510"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80712-6"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.52.37105"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(99)00024-6"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00385-3"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.20725","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.20725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:07:27Z","timestamp":1760414847000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.20725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,13]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1002\/dvdy.20725"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.20725","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,13]]}}}