{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:46:04Z","timestamp":1788893164986,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T00:00:00Z","timestamp":1144022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the search for genetic markers for assessing the role of duct cells in pancreas growth, we examined whether carbonic anhydrase II (CAII) has ductal cell specificity. We determined the distribution and timing of CAII expression in mouse pancreas from embryonic stage to adult. The pancreatic ducts only start expressing CAII at embryonic day (E) 18.5, with increases after birth. Around E15.5, glucagon\u2010positive cells, but not insulin\u2010positive cells, also express CAII, with further increases by adult. CAII expression was restricted to cells within ductal structures and glucagon\u2010positive cells with no colocalization with any insulin\u2010positive cells at any time. In the human pancreas, CAII expression is restricted to the ducts. Furthermore, the activity of a 1.6\u2010kb fragment of the human promoter with Luciferase assays was moderately strong compared with the cytomegalovirus promoter in human pancreatic duct cell line (PANC\u20101). Thus, we believe that the CAII gene could serve as a useful pancreatic duct cell marker. Developmental Dynamics 235:1571\u20131577, 2006.\u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.20754","type":"journal-article","created":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T11:48:46Z","timestamp":1144064926000},"page":"1571-1577","source":"Crossref","is-referenced-by-count":33,"title":["Timing and expression pattern of carbonic anhydrase II in pancreas"],"prefix":"10.1002","volume":"235","author":[{"given":"Akari","family":"Inada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Nienaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonya","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Bonner\u2010Weir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540104900812"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.12.1715"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1399-543X.2004.00075.x","article-title":"The pancreatic ductal epithelium serves as a 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