{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:46:35Z","timestamp":1791150395346,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T00:00:00Z","timestamp":1144195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In mouse embryos, the Zfhx1 transcription factor genes, <jats:italic>Sip1<\/jats:italic> and <jats:italic>\u03b4EF1<\/jats:italic>, are expressed in complementary domains in many tissues. Their possible synergism in embryogenesis was investigated by comparing the phenotype of <jats:italic>Sip1\u2212\/\u2212;\u03b4EF1\u2212\/\u2212<\/jats:italic> double homozygotes with single homozygous embryos. Unexpectedly, in <jats:italic>Sip1\u2212\/\u2212<\/jats:italic> embryos <jats:italic>\u03b4EF1<\/jats:italic> was ectopically activated, suggesting a negative regulation of <jats:italic>\u03b4EF1<\/jats:italic> expression by Sip1. <jats:italic>Sip1\u2212\/\u2212;\u03b4EF1\u2212\/\u2212<\/jats:italic> embryos were similar to <jats:italic>Sip1\u2212\/\u2212<\/jats:italic> embryos in short somite production and developmental arrest around E8.5, but showed more severe defects in dorsal neural tube morphogenesis accompanied by a larger reduction of <jats:italic>Sox2<\/jats:italic> expression, ascribable to the loss of the ectopic <jats:italic>\u03b4EF1<\/jats:italic> expression. <jats:italic>Sip1+\/\u2212;\u03b4EF1\u2212\/\u2212<\/jats:italic> embryos develop various morphological defects after E10 that were absent in <jats:italic>\u03b4EF1\u2212\/\u2212<\/jats:italic> embryos even in tissues without significant overlap of <jats:italic>Sip1<\/jats:italic> and <jats:italic>\u03b4EF1<\/jats:italic> expression, and arrested during mid gestation earlier than <jats:italic>\u03b4EF1\u2212\/\u2212<\/jats:italic> embryos. These findings indicate that complex synergistic interactions occur between Zfhx1 transcription factor genes during mouse embryogenesis. Developmental Dynamics 235:1941\u20131952, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.20799","type":"journal-article","created":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T08:41:19Z","timestamp":1144312879000},"page":"1941-1952","source":"Crossref","is-referenced-by-count":65,"title":["Complementary expression pattern of <i>Zfhx1<\/i> genes <i>Sip1<\/i> and <i>\u03b4EF1<\/i> in the mouse embryo and their genetic interaction revealed by compound mutants"],"prefix":"10.1002","volume":"235","author":[{"given":"Tomoya","family":"Miyoshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuji","family":"Maruhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Van De 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