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The blastopore (marginal zone) acts as a source region that generates primary AP\u2010positional information for the brain, a process that is largely independent of the organizer. This evolutionary old system was once organizing the single axis of radial\u2013symmetric ancestors. Second, the trunk is assumed to be an evolutionary later addition. The AP organization of the trunk depends on a time\u2010controlled posterior transformation in which an oscillation plays a crucial role. This oscillation also leads to the repetitive nature of the trunk pattern as seen in somites or segments. The function of the Spemann\u2010type organizer is not to specify the dorsoventral (DV) positional information directly but to initiate the formation of a stripe\u2010shaped midline organizer, realized with different structures in the brain and in the trunk (prechordal plate vs. notochord). The distance of the cells to this midline (rather than to the organizer) is crucial for the DV specification. The basically different modes of axes formation in vertebrates and insects is proposed to have their origin in the initial positioning of the mesoderm. Only in vertebrates the mesoderm is initiated in a ring at a posterior position. Thus, only in vertebrates complex tissue movements are required to transform the ring\u2010shaped posterior mesoderm into the rod\u2010shaped axial structures. Developmental Dynamics 235:2907\u20132919, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.20952","type":"journal-article","created":{"date-parts":[[2006,9,6]],"date-time":"2006-09-06T17:54:22Z","timestamp":1157565262000},"page":"2907-2919","source":"Crossref","is-referenced-by-count":49,"title":["Primary body axes of vertebrates: Generation of a near\u2010Cartesian coordinate system and the role of Spemann\u2010type 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