{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:04:45Z","timestamp":1778274285761,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T00:00:00Z","timestamp":1163462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Crim1 is a transmembrane protein, containing six vWF\u2010C type cysteine\u2010rich repeats, that tethers growth factors to the cell surface. A mouse line, KST264, generated in a LacZ insertion mutagenesis gene\u2010trap screen, was examined to elucidate Crim1 function in development. We showed that <jats:italic>Crim1<\/jats:italic><jats:sup>KST264\/KST264<\/jats:sup> mice were not null for Crim1 due to the production of a shortened protein isoform. These mice are likely to represent an effective hypomorph or a dominant\u2010negative for Crim1. Transgene expression recapitulated known Crim1 expression in lens, brain, and limb, but also revealed expression in the smooth muscle cells of the developing heart and renal vasculature, developing cartilage, mature ovary and detrusor of the bladder. Transgene expression was also observed in glomerular epithelial cells, podocytes, mesangial cells, and urothelium in the kidney. <jats:italic>Crim1<\/jats:italic><jats:sup>KST264\/KST264<\/jats:sup> mice displayed perinatal lethality, syndactyly, eye, and kidney abnormalities. The severe and complex phenotype observed in <jats:italic>Crim1<\/jats:italic><jats:sup>KST264\/KST264<\/jats:sup> mice highlights the importance of Crim1 in numerous aspects of organogenesis. Developmental Dynamics 236:502\u2013511, 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21015","type":"journal-article","created":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T14:03:53Z","timestamp":1163772233000},"page":"502-511","source":"Crossref","is-referenced-by-count":48,"title":["<i>Crim1<\/i><sup>KST264\/KST264<\/sup> mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems"],"prefix":"10.1002","volume":"236","author":[{"given":"David J.","family":"Pennisi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorine","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Kolle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael 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