{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:40:45Z","timestamp":1791229245061,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T00:00:00Z","timestamp":1163376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In mammals, the ultimobranchial body derived from the fourth pharyngeal pouch gives rise to thyroid C cells. The C cells of newborn mice are immunoreactive for calcitonin, calcitonin gene\u2013related peptide (CGRP), protein gene product (PGP) 9.5 and NeuroD, and transiently exhibit the neuronal markers TuJ1 and somatostatin during fetal development. The basic helix\u2010loop\u2010helix (bHLH) transcription factor Mash1 plays a role in the differentiation of autonomic neurons. We show that in wild\u2010type mouse embryos, Mash1 is expressed in the ultimobranchial body at embryonic day (E) 12.5, when the body is located close to the great arch arteries. It is also expressed in the ultimobanchial body fused with the thyroid lobe at E 13.5. Targeted disruption of <jats:italic>Mash1<\/jats:italic> resulted in the absence of C cells in the mouse thyroid glands, since cells displaying the C\u2010cell markers and expressing NeuroD were not detected during fetal development or at birth. The failure of C\u2010cell formation in the null mutant thyroids was also confirmed by electron microscopy. While the formation and migration of the ultimobranchial body were not affected in the <jats:italic>Mash1<\/jats:italic> null mutants, at E 12.5\u2013E 13.5 both the ultimobranchial body located close to the arteries and the organ populating the thyroid lobe exhibited a marked increase in apoptotic cell numbers. Thus, in the mutant mice, the ultimobranchial body fails to complete its differentiation program and finally dies. These results indicate that Mash1 enhances survival of the C\u2010cell progenitors by inhibiting apoptosis. Developmental Dynamics 236:262\u2013270, 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21018","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T19:43:52Z","timestamp":1163447032000},"page":"262-270","source":"Crossref","is-referenced-by-count":30,"title":["<i>Mash1<\/i> regulates the development of C cells in mouse thyroid glands"],"prefix":"10.1002","volume":"236","author":[{"given":"Yoko","family":"Kameda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Nishimaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010Xu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Guillemot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1242\/dev.122.1.309","article-title":"Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash\u20101\n                  \u2010dependence","volume":"122","author":"Blaugrund E","year":"1996","journal-title":"Development"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/386852a0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.8.1611"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-1042-z"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"6167","DOI":"10.1523\/JNEUROSCI.15-09-06167.1995","article-title":"Induction of a serotonergic and neuronal phenotype in thyroid C\u2013cells","volume":"15","author":"Clark MS","year":"1995","journal-title":"J. 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