{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:44:37Z","timestamp":1776109477534,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,12,28]],"date-time":"2006-12-28T00:00:00Z","timestamp":1167264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spatial\u2013temporal regulation of bone morphogenetic protein (BMP) and Wnt activity is essential for normal cardiovascular development, and altered activity of these growth factors causes maldevelopment of the cardiac outflow tract and great arteries. In the present study, we show that <jats:italic>SOST<\/jats:italic>, a Dan family member reported to antagonize BMP and Wnt activity, is expressed within the medial vessel wall of the great arteries containing smooth muscle cells. The ascending aorta, aortic arch, brachiocephalic artery, common carotids, and pulmonary trunk were all associated with <jats:italic>SOST<\/jats:italic> expressing smooth muscle cells, while the heart itself, including the valves, and more distal arteries, that is, pulmonary arteries, subclavian arteries, and descending aorta, were negative. <jats:italic>SOST<\/jats:italic> was expressed from embryonic day 15.5 up to the neonatal period. <jats:italic>SOST<\/jats:italic> expression, however, did not correspond with inhibition of Smad\u2010dependent BMP activity or \u03b2\u2010catenin\u2013dependent Wnt activity in the great arteries. Activity of both signaling pathways was already down\u2010regulated before induction of <jats:italic>SOST<\/jats:italic> expression. Developmental Dynamics 236:606\u2013612, 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21054","type":"journal-article","created":{"date-parts":[[2006,12,28]],"date-time":"2006-12-28T16:48:41Z","timestamp":1167324521000},"page":"606-612","source":"Crossref","is-referenced-by-count":42,"title":["<i>SOST<\/i> expression is restricted to the great arteries during embryonic and neonatal cardiovascular development"],"prefix":"10.1002","volume":"236","author":[{"given":"Rutger L.","family":"van Bezooijen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco C.","family":"DeRuiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Vilain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui 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