{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:51:59Z","timestamp":1790232719114,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T00:00:00Z","timestamp":1169769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human foregut malformation known as esophageal atresia with tracheoesophageal fistula (EA\/TEF) occurs in 1 in 4,000 live births with unknown etiology. We found that mice lacking <jats:italic>Noggin<\/jats:italic> (<jats:italic>Nog<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>) displayed Type C EA\/TEF, the most common form in humans, and notochordal defects strikingly similar to the adriamycin\u2010induced rat EA\/TEF model. In accord with esophageal atresia, <jats:italic>Nog<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> embryos displayed reduction in the dorsal foregut endoderm, which was associated with reduced adhesion and disrupted basement membrane. However, significant apoptosis in the <jats:italic>Nog<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> dorsal foregut was not observed. Instead, non\u2010notochordal, likely endodermal, cells were found in <jats:italic>Nog<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> notochord, suggesting that <jats:italic>Noggin<\/jats:italic> function is required in the notochordal plate for its proper delamination from the dorsal foregut. Notably, ablating <jats:italic>Bmp7<\/jats:italic> function in <jats:italic>Nog<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> embryos rescued EA\/TEF and notochord branching defects, establishing a critical role of Noggin\u2010mediated Bmp7 antagonism in EA\/TEF pathogenesis. Developmental Dynamics 236:746\u2013754, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21075","type":"journal-article","created":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T17:16:16Z","timestamp":1169831776000},"page":"746-754","source":"Crossref","is-referenced-by-count":72,"title":["Aberrant Bmp signaling and notochord delamination in the pathogenesis of esophageal atresia"],"prefix":"10.1002","volume":"236","author":[{"given":"Yina","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Litingtung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ten Dijke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003830000426"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2005.04.010"},{"key":"e_1_2_5_4_1","first-page":"910","article-title":"Esophageal atresia and tracheoesophageal fistula","volume":"59","author":"Clark DC","year":"1999","journal-title":"Am Fam Physician"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0214"},{"key":"e_1_2_5_6_1","first-page":"104","article-title":"Common pediatric esophageal disorders","volume":"6","author":"del Rosario JF","year":"1998","journal-title":"Gastroenterologist"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90482-0"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199703)208:3<349::AID-AJA6>3.0.CO;2-I"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1995.01430050052008"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)37598-1"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-003-1129-8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.30252"},{"key":"e_1_2_5_13_1","first-page":"1","article-title":"Some aspects of the development of the notochord in mouse embryos","volume":"32","author":"Jurand A","year":"1974","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.18.3623"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00310060"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.03.009"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600124103"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/1717"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.22.2808"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(94)00326-I"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.10.1438"},{"key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"P2749","DOI":"10.1242\/dev.120.10.2749","article-title":"Function of the retinoic acid receptors (RARs) during development (II). 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