{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:05:24Z","timestamp":1791007524922,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,2,5]],"date-time":"2007-02-05T00:00:00Z","timestamp":1170633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The specification of a germ cell as sperm or oocyte and determination of cell number remain unsolved questions in developmental biology. This paper examines <jats:italic>Caenorhabditis elegans<\/jats:italic> FOG\u20101, a CPEB\u2010related RNA\u2010binding protein that controls the sperm fate. We find that abundant FOG\u20101 protein is observed transiently in germ cells just prior to their expression of an early sperm\u2010differentiation marker. As the germline tissue elongates, abundant FOG\u20101 appears more and more distally as sperm become specified, but disappears when the germ line switches to oogenesis. This dynamic pattern is controlled by both globally acting and germline\u2010specific sex\u2010determining regulators. Importantly, the extent of FOG\u20101 expression corresponds roughly to sperm number in wild\u2010type and mutants, altering sperm number. By contrast, three other key regulators of the sperm\/oocyte decision do not similarly correspond to sperm number. We suggest that FOG\u20101 is precisely modulated in both time and space to specify sperm fate and control sperm number. Developmental Dynamics 236:871\u2013879, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21081","type":"journal-article","created":{"date-parts":[[2007,2,5]],"date-time":"2007-02-05T18:19:37Z","timestamp":1170699577000},"page":"871-879","source":"Crossref","is-referenced-by-count":28,"title":["Developmental expression of FOG\u20101\/CPEB protein and its control in the <i>Caenorhabditis elegans<\/i> hermaphrodite germ line"],"prefix":"10.1002","volume":"236","author":[{"given":"Liana B.","family":"Lamont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Kimble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/349346a0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05289.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504593102"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/125.1.29"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/115.1.107"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2004.07.010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/77.1.71"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.14.3119"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.18.2314"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.24.5265"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81961-3"},{"key":"e_1_2_6_13_1","first-page":"193","volume-title":"Basic methods in microscopy: protocols and concepts from cells: a laboratory manual","author":"Crittenden S","year":"2006"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature754"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.47.091201.145251"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00322-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/139.2.561"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","unstructured":"EllisR SchedlT.2005. 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