{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:15:11Z","timestamp":1790871311603,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T00:00:00Z","timestamp":1174867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The embryonic chick is able to regenerate the retina after it has been removed. We have previously shown that proliferating stem\/progenitor cells present in the ciliary body\/ciliary marginal zone (CB\/CMZ) of the chick eye are responsible for regeneration, which can be induced by ectopic fibroblast growth factor\u20102 (FGF2) or Sonic hedgehog (Shh). Here, we reveal the mechanisms showing how FGF2 and Shh signaling are interdependent during retina regeneration. If the FGF pathway is inhibited, regeneration stimulated by Shh is inhibited. Likewise, if the Hedgehog pathway is inhibited, regeneration stimulated by FGF2 is inhibited. We examined early signaling events in the CB\/CMZ and found that FGF2 or Shh induced a robust Erk phosphorylation during the early stages of retina regeneration. Shh also up\u2010regulated the expression of several members of the FGF signaling pathway. We show that ectopic FGF2 or Shh overexpression increased the number of phosphohistone 3 (PH3)\u2010positive cells in the CB\/CMZ and inhibition of either pathway decreased the number of PH3\u2010positive cells. Additionally, both FGF and Hh signaling are required for cell survival in the CB\/CMZ, whereas Hh and not FGF signaling plays a role in maintaining the identity of the retinal progenitor population in this region. Combined, our results support a model where the FGF and Hedgehog pathways work together to stimulate retina regeneration. Developmental Dynamics 236:1161\u20131174, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21115","type":"journal-article","created":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T17:18:03Z","timestamp":1174929483000},"page":"1161-1174","source":"Crossref","is-referenced-by-count":45,"title":["Fibroblast growth factor\u2013hedgehog interdependence during retina regeneration"],"prefix":"10.1002","volume":"236","author":[{"given":"Jason R.","family":"Spence","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan\u2010Carlos","family":"Aycinena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Del 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