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Here, we performed a search for new genes expressed during pancreatic development and have studied the spatiotemporal expression pattern and possible role of <jats:italic>calsenilin<\/jats:italic> in pancreatic development in zebrafish. We detected <jats:italic>calsenilin<\/jats:italic> transcripts in the pancreas from 21 somites to 39 hours postfertilization stages. Using double in situ hybridization, we found that the <jats:italic>calsenilin<\/jats:italic> gene was expressed in pancreatic endocrine cells. Loss\u2010of\u2010function experiments with anti\u2010<jats:italic>calsenilin<\/jats:italic> morpholinos demonstrated that injected morphants have a significant decrease in the number of pancreatic endocrine cells. Furthermore, the knockdown of <jats:italic>calsenilin<\/jats:italic> leads to perturbation in islet morphogenesis, suggesting that <jats:italic>calsenilin<\/jats:italic> is required for early islet cell migration. Taken together, our results show that zebrafish <jats:italic>calsenilin<\/jats:italic> is involved in endocrine cell differentiation and morphogenesis within the pancreas. Developmental Dynamics 236:1517\u20131525, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21149","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T18:19:19Z","timestamp":1177093159000},"page":"1517-1525","source":"Crossref","is-referenced-by-count":9,"title":["Calsenilin is required for endocrine pancreas development in 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