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These are the markers characteristic for embryonic stem cells, epiblast stem cells, and primordial germ cells (PGC). The presence of these stem cells in adult BM supports the concept that this organ contains some population of pluripotent stem cells that is deposited in embryogenesis during early gastrulation. We hypothesize that these cells could be direct descendants of the germ lineage that, to pass genes on to the next generations, has to create soma and, thus, becomes a \u201cmother lineage\u201d for all somatic cell lineages present in the adult body. Germ potential is established after conception in totipotent zygotes and retained in blastomeres of morula, cells from the inner cell mass of blastocyst, epiblast, and population of PGC. We will present a concept that SSEA<jats:sup>+<\/jats:sup> Oct\u20104<jats:sup>+<\/jats:sup> Nanog<jats:sup>+<\/jats:sup> cells identified in BM could be descendants of epiblast cells as well as some rare migrating astray PGC. Developmental Dynamics 236:3309\u20133320, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21180","type":"journal-article","created":{"date-parts":[[2007,5,11]],"date-time":"2007-05-11T15:49:37Z","timestamp":1178898577000},"page":"3309-3320","source":"Crossref","is-referenced-by-count":36,"title":["Bone marrow\u2010derived very small embryonic\u2010like stem cells: Their developmental origin and biological significance"],"prefix":"10.1002","volume":"236","author":[{"given":"M.","family":"Kucia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.Z.","family":"Ratajczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147780.30124.CF"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02069"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9912"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-030551"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-02-0079"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4157(91)90014-N"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1682"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2006.05.009"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.10.2131"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-4-8"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.297.5585.1299"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1097071"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.141221698"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm959"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10455"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2002.5543"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01103"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gal096"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1274"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(83)90421-4"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2004.03.017"},{"key":"e_1_2_13_23_1","first-page":"1043","article-title":"The 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