{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:31:44Z","timestamp":1760401904439,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,9,6]],"date-time":"2007-09-06T00:00:00Z","timestamp":1189036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Williams syndrome is a rare congenital disorder involving the cardiovascular system, mental retardation, distinctive facial features, and tooth anomalies. It is caused by the heterozygous deletion of \u223c1.6 Mb encompassing 28 genes on human chromosome 7q11.23. It has been suggested that the genes responsible for craniofacial anomalies are located in the telomeric end region, which harbors three members of the <jats:italic>TFII<\/jats:italic>\u2010<jats:italic>I<\/jats:italic> gene family (Tassabehji et al. [] Science 310:1184). To recognize potential candidate genes for the tooth anomalies in Williams syndrome, we carried out comparative in situ hybridization analysis of members of <jats:italic>TFII<\/jats:italic>\u2010<jats:italic>I<\/jats:italic> gene family during murine odontogenesis. <jats:italic>Gtf2i<\/jats:italic> showed widespread expression in the developing head but was higher in the developing teeth than surrounding tissues throughout tooth development. At the bud stage, <jats:italic>Gtf2ird1<\/jats:italic> and <jats:italic>Gtf2ird2<\/jats:italic> were expressed in the epithelial buds. At the early bell stage, expression of <jats:italic>Gtf2ird1<\/jats:italic> and <jats:italic>Gtf2ird2<\/jats:italic> was observed in preameloblasts and preodontoblasts. Developmental Dynamics 236:2884\u20132888, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21311","type":"journal-article","created":{"date-parts":[[2007,9,6]],"date-time":"2007-09-06T14:46:51Z","timestamp":1189090011000},"page":"2884-2888","source":"Crossref","is-referenced-by-count":18,"title":["<i>TFII\u2010I<\/i> gene family during tooth development: Candidate genes for tooth anomalies in Williams syndrome"],"prefix":"10.1002","volume":"236","author":[{"given":"Atsushi","family":"Ohazama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul T.","family":"Sharpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,6]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"15","volume-title":"In situ hybridisation: a practical approach","author":"Angerer LM","year":"1992"},{"key":"e_1_2_5_3_1","first-page":"3","article-title":"Variability of the cranial and dental phenotype in Williams syndrome","author":"Axelsson S","year":"2005","journal-title":"Swed Dent J"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350310001451"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.13.7342"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-133X(03)00118-2"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(200022)97:2<164::AID-AJMG8>3.0.CO;2-F"},{"key":"e_1_2_5_8_1","first-page":"262","article-title":"Williams syndrome\u2014oral presentation of 45 cases","volume":"16","author":"Hertzberg J","year":"1994","journal-title":"Pediatr Dent"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.76.901.712"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.1.1.461"},{"key":"e_1_2_5_11_1","first-page":"199","volume-title":"Molecular basis of inborn errors of development","author":"Ohazama A","year":"2003"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.11.6641"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modgep.2006.11.008"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.23.7091"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.79.930.241"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200396"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116142"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201174"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199808)212:4<533::AID-AJA6>3.0.CO;2-I"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.21311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.21311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:10:41Z","timestamp":1760361041000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.21311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,6]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1002\/dvdy.21311"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.21311","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"type":"print","value":"1058-8388"},{"type":"electronic","value":"1097-0177"}],"subject":[],"published":{"date-parts":[[2007,9,6]]}}}