{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:38:56Z","timestamp":1790620736370,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,2,24]],"date-time":"2008-02-24T00:00:00Z","timestamp":1203811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>SP6 belongs to the SP\/KLF family of transcription factors, characterized by a DNA\u2010binding domain composed of three zinc fingers of the C<jats:sub>2<\/jats:sub>H<jats:sub>2<\/jats:sub> type. The <jats:italic>Sp6<\/jats:italic> gene generates two different transcripts, termed <jats:italic>Sp6<\/jats:italic> and epiprofin, which differ in the first exon and encode the same SP6 protein. These transcripts are mainly expressed in the skin, the teeth, and the limb buds of embryos and also in the adult lungs. To gain insight into the biological function of the SP6 protein, we knocked out the gene by eliminating the full coding region. The resulting <jats:italic>Sp6<\/jats:italic> null mice are nude, lack functional teeth, and present limb and lung malformations. We also showed that the identified abnormalities are associated with apoptotic misregulations. In conclusion, this work indicates that <jats:italic>Sp6<\/jats:italic> plays a critical role in the development of several epithelium\u2010containing organs or appendages, possibly by regulating apoptosis. Developmental Dynamics 237:883\u2013892, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21355","type":"journal-article","created":{"date-parts":[[2008,2,25]],"date-time":"2008-02-25T02:22:52Z","timestamp":1203906172000},"page":"883-892","source":"Crossref","is-referenced-by-count":31,"title":["The development of several organs and appendages is impaired in mice lacking Sp6"],"prefix":"10.1002","volume":"237","author":[{"given":"Val\u00e9rie","family":"Hertveldt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Louryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"van Reeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Dr\u00e8ze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"van Vooren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane","family":"Szpirer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Szpirer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100043200"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(00)88932-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00221-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2000.1142"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000103930.93849.B2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05659"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(92)90350-D"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588702400207"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2007.05.011"},{"key":"e_1_2_6_11_1","volume-title":"Manipulating the mouse embryo: a laboratory manual","author":"Hogan B","year":"1994"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi381"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305650200"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711050103"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500610"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008868325009"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01975"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307502200"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(90)90041-S"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.08.006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20184"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6362"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1997.062.01.032"},{"key":"e_1_2_6_24_1","first-page":"743","article-title":"In toto alcian blue staining of the cartilaginous skeleton in mammalian embryos","volume":"184","author":"Watson AG","year":"1977","journal-title":"Anat Rec"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-169X.2005.00797.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2004.12.004"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.21355","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.21355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:35:28Z","timestamp":1760369728000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.21355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,19]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1002\/dvdy.21355"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.21355","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,19]]}}}