{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:58:27Z","timestamp":1791615507951,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,19]],"date-time":"2007-12-19T00:00:00Z","timestamp":1198022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the expression profiles of <jats:italic>tDMRT1<\/jats:italic> and <jats:italic>Sox9a<\/jats:italic> during gonadal sex differentiation and hormone\u2010induced sex reversal. <jats:italic>tDMRT1<\/jats:italic> was detected in the gonial germ\u2010cell\u2013surrounding cells in XY fry specifically before the appearance of any signs of morphological sex differentiation, that is, sex differences in germ cell number and histogenesis, such as differentiation into intratesticular efferent duct or ovarian cavity. The signals became localized in the Sertoli and epithelial cells comprising the efferent duct during gonadal differentiation. After the induction of XY sex reversal with estrogen, <jats:italic>tDMRT1<\/jats:italic> decreased and then disappeared completely. In contrast, <jats:italic>tDMRT1<\/jats:italic> was expressed in the germ\u2010cell\u2013surrounding cells in XX sex reversal with androgen. On the other hand, <jats:italic>Sox9a<\/jats:italic> did not show sexual dimorphism before the appearance of sex differences in histogenesis and was not expressed in the efferent duct in the testis. These results suggest that <jats:italic>tDMRT1<\/jats:italic> is a superior testicular differentiation marker in tilapia. Developmental Dynamics 237:297\u2013306, 2008. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21409","type":"journal-article","created":{"date-parts":[[2007,12,19]],"date-time":"2007-12-19T20:49:03Z","timestamp":1198097343000},"page":"297-306","source":"Crossref","is-referenced-by-count":163,"title":["Sexual dimorphic expression of <i>DMRT1<\/i> and <i>Sox9a<\/i> during gonadal differentiation and hormone\u2010induced sex reversal in the teleost fish Nile tilapia (<i>Oreochromis niloticus<\/i>)"],"prefix":"10.1002","volume":"237","author":[{"given":"Tohru","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Kajiura\u2010Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guijun","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Nagahama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050344"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.30.6.518"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2005.06.014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00327-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(99)00152-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.3.1167"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.0129"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.1.42"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00282-8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb05684.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/302016"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2840"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.03.066"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074354"},{"key":"e_1_2_6_16_1","first-page":"49","article-title":"X\u2010chromosome inactivation during the development of the male urogenital ridge of the mouse","volume":"41","author":"Jameson RV","year":"1997","journal-title":"Int J Dev Biol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8925"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1526-968X(200003)26:3<174::AID-GENE2>3.0.CO;2-J"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.133.1.321"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(00)00464-0"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00613-X"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074351"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20158"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(00)00186-X"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5385.1990"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature751"},{"key":"e_1_2_6_27_1","first-page":"159","article-title":"Oryzias curvinotus has DMY, a gene that is required for male development in the medaka, O. latipes. 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