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Nuclear factor kB (NF\u2010kB) is a transcription factor central to multiple inflammatory and developmental pathways, including dorsal\u2013ventral patterning in fruit flies, limb and mammary and submandibular gland development in mice, and branching morphogenesis in chick lungs. Given its shared role in inflammation and developmental signaling, we hypothesized that overexpression of NF\u2010kB targeted to the lung epithelium would exert maturational effects on alveolar development. We generated transgenic mice with lung\u2010specific overexpression of the RelA subunit of NF\u2010kB using a surfactant protein C promoter construct. Our results showed that RelA overexpression in the lung yields increased alveolar type I and type II cells. These findings are consistent with a model whereby NF\u2010kB may induce maturation of lung development through decreased apoptosis of epithelial cells. Developmental Dynamics 237:328\u2013338, 2008. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21413","type":"journal-article","created":{"date-parts":[[2007,12,27]],"date-time":"2007-12-27T02:46:57Z","timestamp":1198723617000},"page":"328-338","source":"Crossref","is-referenced-by-count":31,"title":["NF\u2010kB induces lung maturation during mouse lung morphogenesis"],"prefix":"10.1002","volume":"237","author":[{"given":"Vedang A.","family":"Londhe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanh 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