{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:18:28Z","timestamp":1789615108108,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,1,21]],"date-time":"2008-01-21T00:00:00Z","timestamp":1200873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Connective tissue growth factor (CTGF) is a mediator of growth factor activity, and <jats:italic>Ctgf<\/jats:italic> knockouts die at birth from respiratory failure due to skeletal dysplasia. Previous microarray analysis revealed <jats:italic>Ctgf<\/jats:italic> down\u2010regulation in the hypoplastic lungs of amyogenic mouse embryos. This study, therefore, examined pulmonary development in <jats:italic>Ctgf\u2212\/\u2212<\/jats:italic> mouse fetuses to investigate if respiration could also have been impaired by lung abnormalities. The <jats:italic>Ctgf\u2212\/\u2212<\/jats:italic> lungs were hypoplastic, with reduced cell proliferation and increased apoptosis. PDGF\u2010B, its receptor and IGF\u2010I, were markedly attenuated and the TTF\u20101 gradient lost. Type II pneumocyte differentiation was perturbed, the cells depicting excessive glycogen retention and diminished lamellar body and nuclear size, though able to synthesize surfactant\u2010associated protein. However, type I pneumocyte differentiation was not affected by <jats:italic>Ctgf<\/jats:italic> deletion. Our findings indicate that the absence of <jats:italic>Ctgf<\/jats:italic> and\/or its protein product, CTGF, may induce pulmonary hypoplasia by both disrupting basic lung developmental processes and restricting thoracic expansion. Developmental Dynamics 237:485\u2013493, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21433","type":"journal-article","created":{"date-parts":[[2008,1,21]],"date-time":"2008-01-21T21:46:31Z","timestamp":1200951991000},"page":"485-493","source":"Crossref","is-referenced-by-count":58,"title":["Pulmonary hypoplasia in the connective tissue growth factor (<i>Ctgf<\/i>) null mouse"],"prefix":"10.1002","volume":"237","author":[{"given":"Mark","family":"Baguma\u2010Nibasheka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Kablar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000031828.58276.02"},{"key":"e_1_2_6_3_1","first-page":"736","article-title":"Derivation of type 1 epithelium from type 2 cells in 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