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Here, we show that mice carrying a conditional inactivation of <jats:italic>Shox2<\/jats:italic> in the palatal mesenchyme survive the embryonic and neonatal lethality, but develop a wasting syndrome. Phenotypic analyses indicate a delayed closure of the secondary palate at the anterior end, leading to a failed fusion of the primary and secondary palates. Consistent with a role proposed for <jats:italic>Shox2<\/jats:italic> in skeletogenesis, <jats:italic>Shox2<\/jats:italic> inactivation causes a significantly reduced bone formation in the hard palate, probably due to a down\u2010regulation of <jats:italic>Runx2<\/jats:italic> and <jats:italic>Osterix<\/jats:italic>. We conclude that the secondary palatal shelves are capable of fusion with each other, but fail to fuse with the primary palate in a developmentally delayed manner. Mice carrying an anterior cleft can survive neonatal lethality. Developmental Dynamics 237:1509\u20101516, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21534","type":"journal-article","created":{"date-parts":[[2008,4,4]],"date-time":"2008-04-04T19:16:19Z","timestamp":1207336579000},"page":"1509-1516","source":"Crossref","is-referenced-by-count":27,"title":["Mice with an anterior cleft of the palate survive neonatal lethality"],"prefix":"10.1002","volume":"237","author":[{"given":"Shuping","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiPing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540405200113"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.09.010"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0198-67"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/8792"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.637819"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.8.1671"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1242\/dev.122.10.3035","article-title":"Msx1 controls inductive signaling in mammalian tooth development","volume":"122","author":"Chen YP","year":"1996","journal-title":"Development"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.5.695"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510544103"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(07)00562-3"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80257-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.8.1341"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197107000-00009"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.103.Supplement.41"},{"key":"e_1_2_5_16_1","first-page":"225","article-title":"Developmental aspects of secondary palate formation","volume":"36","author":"Greene RM","year":"1976","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.07.042"},{"key":"e_1_2_5_18_1","unstructured":"GuS WeiN FeiJ ChenYP.Shox2\u2010deficiency leads to dysplasia and ankylosis of the temporomandibular joint in mice. 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