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Improper migration and differentiation of these NCCs have been implicated in human diseases such as congenital glaucoma and anterior segment dysgenesis syndromes. The mechanisms by which these cells migrate to their target tissues within and around the eye are not well understood. We present a fate map of zebrafish diencephalic and mesencephalic NCC contributions to the eye and orbit. The fate map closely resembles that in chick and mice, demonstrating evolutionary conservation. To gain insight into the mechanisms of anterior NCC guidance, we used the eyeless mutant <jats:italic>chokh<\/jats:italic>\/rx3. We show that, in <jats:italic>chokh<\/jats:italic> mutants, dorsal anterior NCC migration is severely disorganized. Time\u2010lapse analysis shows that NCCs have significantly reduced migration rates and directionality in <jats:italic>chokh<\/jats:italic> mutants. Developmental Dynamics 237:1645\u20131652, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21577","type":"journal-article","created":{"date-parts":[[2008,5,22]],"date-time":"2008-05-22T12:47:59Z","timestamp":1211460479000},"page":"1645-1652","source":"Crossref","is-referenced-by-count":83,"title":["The eye organizes neural crest cell migration"],"prefix":"10.1002","volume":"237","author":[{"given":"Tobias","family":"Langenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Kahana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Wszalek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary 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