{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T08:37:07Z","timestamp":1785573427636,"version":"3.56.0"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,8,26]],"date-time":"2008-08-26T00:00:00Z","timestamp":1219708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Secreted Frizzled\u2010related protein 2 (Sfrp2) or Stromal Cell Derived Factor\u20105 (SDF\u20105) is highly expressed in the developing limbs. Here we showed the single <jats:italic>Sfrp2<\/jats:italic> inactivation in mice resulted in syndactyly and preaxial synpolydactyly, predominantly in the hindlimbs. Tails were often kinked. A penetrance of the syndactyly was highest in 129\/SvJ or CBA\/N \u00d7 129\/SvJ background and the phenotype was haploinsufficient. Preaxial synpolydactyly was seen in homozygous mutants in C57BL\/6 \u00d7 129\/SvJ. Of note, syndactyly showed retarded apoptosis of the second and the third interdigital spaces; concomitantly, mesodermal <jats:italic>Msx2<\/jats:italic> expression was down\u2010regulated. Impaired digital anlagen maturation was also noticeable in the same position. Preaxial synpolydactyly of the <jats:italic>Sfrp2<\/jats:italic> mutants was a non\u2010mirror image type and <jats:italic>Shh<\/jats:italic> independent. Although joint formation was not disrupted, chondrocyte maturation was preaxially disturbed. Our results suggest that the <jats:italic>Sfrp2<\/jats:italic> deleted mice can be a useful animal model to study human syndactyly\/preaxial synpolydactyly defects. Developmental Dynamics 237:2506\u20132517, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21655","type":"journal-article","created":{"date-parts":[[2008,8,26]],"date-time":"2008-08-26T22:12:49Z","timestamp":1219788769000},"page":"2506-2517","source":"Crossref","is-referenced-by-count":19,"title":["Syndactyly and preaxial synpolydactyly in the single <i>Sfrp<\/i><i>2<\/i> deleted mutant mice"],"prefix":"10.1002","volume":"237","author":[{"given":"Masaya","family":"Ikegawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsue","family":"Omi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahito","family":"Miyamae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Toguchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1171104"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0498"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.9.1129"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5368.1455"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.17.1.87"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0346"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00152"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20507"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5478.438"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.03.016"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024181203729"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8664"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.1242\/dev.127.24.5285","article-title":"The WNT antagonist cSFRP2 modulates programmed cell death in the developing hindbrain","volume":"127","author":"Ellies DL","year":"2000","journal-title":"Development"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0802"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8880"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8843"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20637"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0817"},{"key":"e_1_2_6_20_1","first-page":"983","article-title":"Human limb malformations; 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