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We found that the intensely immunolabeled \u03b2gal<jats:sup>+<\/jats:sup> cells were co\u2010immunolabeled with Nestin and formed a tangentially oriented single\u2010cell layer in the \u201cconnecting or docking zone\u201d where the olfactory sensory axons attached to the brain surface during mid\u2010gestation. During early postnatal development, \u03b2gal<jats:sup>+<\/jats:sup> cells were located in the inner olfactory nerve layer (ONLi) and co\u2010labeled with olfactory ensheathing cell (OEC) markers S100\u03b2 and NPY but not with lineage\u2010specific markers for neurons, oligodendrocytes, astrocytes, and microglia, demonstrating that the TOPgal marked a subpopulation of OECs. By confocal microscopy, we found that TOPgal activated processes extended along the developing glomerulus and formed multiple tunnel\u2010like structures that ensheathe and bridge olfactory sensory axonal bundles from ONLi to the glomerulus, which may play a key role in glomerulus formation and convergent sorting of the peripheral olfactory axons. Developmental Dynamics 237:3157\u20133168, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21712","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T02:27:17Z","timestamp":1222223237000},"page":"3157-3168","source":"Crossref","is-referenced-by-count":20,"title":["Activation of the Wnt\/\u03b2\u2010catenin signaling reporter in developing mouse olfactory nerve layer marks a specialized subgroup of olfactory ensheathing cells"],"prefix":"10.1002","volume":"237","author":[{"given":"Ya\u2010Zhou","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Molotkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanying","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Pleasure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Ji","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,9,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00184745"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10160"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10182"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19991227)415:4<423::AID-CNE2>3.0.CO;2-G"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20582"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20606"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.20.4557"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0027"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.07.013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902950105"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903440303"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.01.013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-12-03310.1985"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00121-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.20.010403.113126"},{"key":"e_1_2_6_17_1","unstructured":"MolotkovA ZhouCJ.2007.Canonical Wnt signaling during mouse olfactory development and regeneration. 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