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We identified two morphologically distinct cell populations at the single bud stage, destined for different functions. The outer layer of columnar cells with organized E\u2010cadherin junctions expressed the neonatal acinar marker B1 by E13.5, demonstrating their acinar fate. The interior cells initially lacked distinct E\u2010cadherin junctions, but with morphogenesis formed cytokeratin 7 (K7) \u2010positive ductal structures with organized E\u2010cadherin junctions and F\u2010actin filaments. Inhibition of E\u2010cadherin function with either siRNA or function blocking antibody caused extensive apoptosis of ductal cells and aberrantly dilated lumens, providing the first evidence that E\u2010cadherin regulates ductal lumen formation during branching morphogenesis of the salivary gland. Developmental Dynamics 237:3128\u20133141, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21717","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T02:27:09Z","timestamp":1222223229000},"page":"3128-3141","source":"Crossref","is-referenced-by-count":87,"title":["Diverse roles of E\u2010cadherin in the morphogenesis of the submandibular gland: Insights into the formation of acinar and ductal structures"],"prefix":"10.1002","volume":"237","author":[{"given":"Janice L.","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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