{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:48:12Z","timestamp":1790246892430,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,10,21]],"date-time":"2008-10-21T00:00:00Z","timestamp":1224547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Prx1<\/jats:italic> and <jats:italic>Prx2<\/jats:italic> are members of the aristaless\u2010related homeobox genes shown to play redundant but essential roles in morphogenesis of the mandibular processes. To gain insight into the signaling pathways that regulate expression of <jats:italic>Prx<\/jats:italic> genes in the mandibular mesenchyme, we used the chick as a model system. We examined the patterns of gene expression in the face and the roles of signals derived from the epithelium on the expression of <jats:italic>Prx<\/jats:italic> genes in the mandibular mesenchyme. Our results demonstrated stage\u2010dependent roles of mandibular epithelium on the expression of <jats:italic>Prx<\/jats:italic> in the mandibular mesenchyme and provide evidence for positive roles of members of the fibroblast and hedgehog families derived from mandibular epithelium on the expression of <jats:italic>Prx<\/jats:italic> genes in the mandibular mesenchyme. Our studies suggest that endothelin\u20101 signaling derived from the mesenchyme is involved in restricting the expression of <jats:italic>Prx2<\/jats:italic> to the medial mandibular mesenchyme. Developmental Dynamics 237:3115\u20133127, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21762","type":"journal-article","created":{"date-parts":[[2008,10,21]],"date-time":"2008-10-21T18:49:35Z","timestamp":1224614975000},"page":"3115-3127","source":"Crossref","is-referenced-by-count":13,"title":["Signaling pathways regulating the expression of <i>Prx1<\/i> and <i>Prx2<\/i> in the chick mandibular mesenchyme"],"prefix":"10.1002","volume":"237","author":[{"given":"Aikaterini\u2010El","family":"Doufexi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Mina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1242\/dev.129.19.4613","article-title":"Fgf8 is required for pharyngeal arch and cardiovascular 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