{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:34:53Z","timestamp":1790408093999,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T00:00:00Z","timestamp":1232582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Heterochronic genes function to ensure the timing of stage\u2010specific developmental events in\n                    <jats:italic>C. elegans<\/jats:italic>\n                    . Mutations in these genes cause certain developmental programs to be executed in a precocious or retarded manner. Canonical precocious (loss\u2010of\u2010function) and retarded (gain\u2010of\u2010function) mutations in the\n                    <jats:italic>lin<\/jats:italic>\n                    \u2010\n                    <jats:italic>14<\/jats:italic>\n                    gene lead to elimination or reiteration of larval stage\u2010specific cellular events. Here, we describe a hypomorphic, missense allele of\n                    <jats:italic>lin<\/jats:italic>\n                    \u2010\n                    <jats:italic>14<\/jats:italic>\n                    ,\n                    <jats:italic>sa485<\/jats:italic>\n                    .\n                    <jats:italic>lin\u201014(sa485<\/jats:italic>\n                    ) hermaphrodites pass through normal larval stages, but exhibit asynchrony between vulval and gonadal maturation in the L4 larval stage. We show that a subtly precocious morphogenetic event in the vulva disrupts tissue synchrony and is followed by retarded vulval eversion. Additionally, uterine uv1 cell differentiation is retarded in\n                    <jats:italic>lin\u201014(sa485<\/jats:italic>\n                    ) animals that exhibit delayed vulval eversion. Together, these experiments outline a function for LIN\u201014 in coordinating the temporal progression of development, which is separable from its role in regulating stage\u2010specific events during\n                    <jats:italic>C. elegans<\/jats:italic>\n                    postembryonic development. Developmental Dynamics 238:394\u2013404, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/dvdy.21837","type":"journal-article","created":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T20:40:36Z","timestamp":1232656836000},"page":"394-404","source":"Crossref","is-referenced-by-count":11,"title":["The\n                    <i>Caenorhabditis elegans<\/i>\n                    heterochronic gene\n                    <i>lin\u201014<\/i>\n                    coordinates temporal progression and maturation in the egg\u2010laying system"],"prefix":"10.1002","volume":"238","author":[{"given":"Ryan W.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah Y.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Hanna\u2010Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"Chamberlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6494891"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1.4.398"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/oso\/9780199637393.003.0006","volume-title":"C. elegans: a practical approach","author":"Barstead RJ","year":"1999"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/77.1.71"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1242\/dev.124.20.3919","article-title":"The PAX Gene egl\u201038 mediates developmental patterning in Caenorhabditis elegans","volume":"124","author":"Chamberlin HM","year":"1997","journal-title":"Development"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80112-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81045-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl444"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.23.3041"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.6.2285-2295.2000"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.24.11059-11072.2005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.08.024"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01278"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90529-Y"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.03.043"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00126-X"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2683077"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00827-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.11.3617"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.011767"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","unstructured":"PriessJR.2005. Notch signaling in theC. elegansembryo. In: The C. elegans Research Community editors. 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