{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T20:11:00Z","timestamp":1769976660643,"version":"3.49.0"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,22]],"date-time":"2009-02-22T00:00:00Z","timestamp":1235260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Hox<\/jats:italic> genes are key players in defining positional information along the main body axis of vertebrate embryos. In <jats:italic>Xenopus laevis, Hoxc6<\/jats:italic> was the first homeobox gene isolated. It encodes two isoforms. We analyzed in detail their spatial and temporal expression pattern during early development. One major expression domain of both isoforms is the spinal cord portion of the neural tube. Within the spinal cord and its populations of primary neurons, <jats:italic>Hox<\/jats:italic> genes have been found to play a crucial role for defining positional information. Here we report that a loss\u2010of\u2010function of either one of the <jats:italic>Hoxc6<\/jats:italic> products does not affect neural induction, the expression of general neural markers is not modified. However, Hoxc6 does widely affect the formation of primary neurons within the developing neural tissue. Manipulations of <jats:italic>Hoxc6<\/jats:italic> expression severly changes the expression of the neuronal markers <jats:italic>N<\/jats:italic>\u2010<jats:italic>tubulin<\/jats:italic> and <jats:italic>Islet<\/jats:italic>\u2010<jats:italic>1<\/jats:italic>. Formation of primary neurons and formation of cranial nerves are affected. Hence, Hoxc6 functions are not restricted to the expected role in anterior\u2010posterior pattern formation, but they also regulate N\u2010tubulin, thereby having an effect on the initial formation of primary neurons in <jats:italic>Xenopus laevis<\/jats:italic> embryos. Developmental Dynamics 238:755\u2013765, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21889","type":"journal-article","created":{"date-parts":[[2009,2,22]],"date-time":"2009-02-22T22:01:56Z","timestamp":1235340116000},"page":"755-765","source":"Crossref","is-referenced-by-count":10,"title":["Two <i>Hoxc6<\/i> transcripts are differentially expressed and regulate primary neurogenesis in <i>Xenopus laevis<\/i>"],"prefix":"10.1002","volume":"238","author":[{"given":"Nabila","family":"Bardine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Donow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Korte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antony 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