{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:45:07Z","timestamp":1789771507499,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T00:00:00Z","timestamp":1237420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leucine\u2010rich repeat (LRR) \u2010containing G protein coupled receptor (LGR) family members are characterized by the presence of a seven\u2010transmembrane domain and LRR motifs. We describe a new function for <jats:italic>Lgr4<\/jats:italic> in the development of the gall bladder and cystic duct and in the epithelium\u2013mesenchyme interaction. <jats:italic>Lgr4<\/jats:italic> expression was observed in the gall bladder epithelium when the gall bladder primordium elongated ventrally. Although <jats:italic>Lgr4<\/jats:italic> hypomorphic mutant (<jats:italic>Lgr4<\/jats:italic><jats:sup><jats:italic>Gt<\/jats:italic>\/<jats:italic>Gt<\/jats:italic><\/jats:sup>) embryos developed a normal gall bladder bud at embryonic day (E) 10.25, no further elongation was observed at later stages. At E12.5, the mesenchyme surrounding the gall bladder had completely disappeared in <jats:italic>Lgr4<\/jats:italic><jats:sup><jats:italic>Gt<\/jats:italic>\/<jats:italic>Gt<\/jats:italic><\/jats:sup> embryos, while the gall bladder remained unelongated. Neighboring tissues such as liver and pancreas were unaffected, as revealed by expression of marker genes. This is the first report of a mutant mouse that lacks a gall bladder and cystic duct without affecting the other tissues that derive from the same hepatic diverticulum. Developmental Dynamics 238:993\u20131000, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21900","type":"journal-article","created":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T12:21:33Z","timestamp":1237465293000},"page":"993-1000","source":"Crossref","is-referenced-by-count":62,"title":["Defective development of the gall bladder and cystic duct in <i>Lgr4<\/i>\u2010 hypomorphic 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