{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:31:54Z","timestamp":1790641914243,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T00:00:00Z","timestamp":1238371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The transcription factor <jats:italic>Pitx3<\/jats:italic> is critical for lens formation. Deletions in the promoter of this gene cause abnormal lens development in the <jats:italic>aphakia<\/jats:italic> (<jats:italic>ak<\/jats:italic>) mouse mutant, which has only rudimentary lenses. In this study, we investigated the role of <jats:italic>Pitx3<\/jats:italic> in lens development and differentiation. We found that reduced expression of <jats:italic>Pitx3<\/jats:italic> leads to changes in the proliferation, differentiation and survival of lens cells. The genetic interactions between <jats:italic>Pitx3<\/jats:italic> and <jats:italic>Foxe3<\/jats:italic> were investigated, as these two transcription factors are expressed at the same time in lens development and their absence has similar consequences for lens development. We found no evidence that these two genes genetically interact. In general, our study shows that the abnormal phenotype of the <jats:italic>ak<\/jats:italic> lenses is not due to just one molecular pathway, rather in the absence of <jats:italic>Pitx3<\/jats:italic> expression multiple aspects of lens development are disrupted. Developmental Dynamics 238:2193\u20132201, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21924","type":"journal-article","created":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T20:57:29Z","timestamp":1238446649000},"page":"2193-2201","source":"Crossref","is-referenced-by-count":44,"title":["Pitx3 controls multiple aspects of lens development"],"prefix":"10.1002","volume":"238","author":[{"given":"Olga","family":"Medina\u2010Martinez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Jamrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.2.245"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.09.021"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1526-968X(200006)27:2<81::AID-GENE50>3.0.CO;2-N"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1300"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.17.1.255"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312414200"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2007.07.002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2006.10.005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.2.4.429"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1144"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.1994.5710031.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0894-463"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6408(1998)23:4<299::AID-DVG5>3.0.CO;2-G"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0294-168"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004120050256"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/354522a0"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0892-328"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2243"},{"key":"e_1_2_6_20_1","first-page":"589","article-title":"[Action of mutant genes on crystallin synthesis in the developing mouse lens. 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