{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:21:41Z","timestamp":1781068901803,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T00:00:00Z","timestamp":1243468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tight regulation of Notch pathway signaling is important in many aspects of embryonic development. Notch signaling can be modulated by expression of <jats:italic>fringe<\/jats:italic> genes, encoding glycosyltransferases that modify EGF repeats in the Notch receptor. Although Lunatic fringe (<jats:italic>Lfng<\/jats:italic>) has been shown to play important roles in vertebrate segmentation, comparatively little is known regarding the developmental functions of the other vertebrate fringe genes, Radical fringe (<jats:italic>Rfng<\/jats:italic>) and Manic fringe (<jats:italic>Mfng<\/jats:italic>). Here we report that <jats:italic>Mfng<\/jats:italic> expression is not required for embryonic development. Further, we find that despite significant overlap in expression patterns, we detect no obvious synergistic defects in mice in the absence of two, or all three, <jats:italic>fringe<\/jats:italic> genes during development of the axial skeleton, limbs, hindbrain, and cranial nerves. Developmental Dynamics 238:1803\u20131812, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.21982","type":"journal-article","created":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T10:33:37Z","timestamp":1243506817000},"page":"1803-1812","source":"Crossref","is-referenced-by-count":48,"title":["Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain"],"prefix":"10.1002","volume":"238","author":[{"given":"Jennifer L.","family":"Moran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily T.","family":"Shifley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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