{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:19:18Z","timestamp":1760487558514,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,8,3]],"date-time":"2009-08-03T00:00:00Z","timestamp":1249257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the frog, <jats:italic>Xenopus laevis<\/jats:italic>, fibroblast growth factor (FGF) signaling is required for both mesoderm formation and the morphogenetic movements that drive the elongation of the notochord, a dorsal mesodermal derivative; the coordination of these distinct roles is mediated by the <jats:italic>Xenopus<\/jats:italic> Ctr1 (Xctr1) protein: maternal Xctr1 is required for mesodermal differentiation, while the subsequent loss of Xctr1 promotes morphogenesis. The signaling cascade activated by FGF in the presence of Ctr1 has been well characterized; however, the Xctr1\u2010independent, FGF\u2010responsive network remains poorly defined. We have identified <jats:italic>Xenopus Marginal Coil<\/jats:italic> (<jats:italic>Xmc<\/jats:italic>) as a gene whose expression is highly enriched following Xctr1 knockdown. Zygotic initiation of <jats:italic>Xmc<\/jats:italic> expression in vivo coincides with a decrease in maternal <jats:italic>Xctr1<\/jats:italic> transcripts; moreover, Xmc loss\u2010of\u2010function inhibits Xctr1 knockdown\u2010mediated elongation of FGF\u2010treated animal cap explants, implicating Xmc as a key effector of Xctr1\u2010independent gastrular morphogenesis. Developmental Dynamics 238:2382\u20132400, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.22050","type":"journal-article","created":{"date-parts":[[2009,8,3]],"date-time":"2009-08-03T16:06:19Z","timestamp":1249315579000},"page":"2382-2387","source":"Crossref","is-referenced-by-count":4,"title":["Xmc mediates Xctr1\u2010independent morphogenesis in <i>Xenopus laevis<\/i>"],"prefix":"10.1002","volume":"238","author":[{"given":"Tomomi","family":"Haremaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel C.","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1242\/dev.110.3.955","article-title":"Post\u2010transcriptional regulation of ornithine decarboxylase in Xenopus laevis oocytes","volume":"110","author":"Bassez T","year":"1990","journal-title":"Development"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00664-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00524-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701413104"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02304"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90319-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/4.2.249"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(89)90300-X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/311716a0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.191301"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2144\/03342mt01"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.02.011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl025"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/376331a0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1242\/dev.109.1.225","article-title":"The Xenopus XIHbox 6 homeo protein, a marker of posterior neural induction, is expressed in proliferating neurons","volume":"109","author":"Wright CV","year":"1990","journal-title":"Development"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.22050","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.22050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T03:56:49Z","timestamp":1760414209000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.22050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,3]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1002\/dvdy.22050"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.22050","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"type":"print","value":"1058-8388"},{"type":"electronic","value":"1097-0177"}],"subject":[],"published":{"date-parts":[[2009,8,3]]}}}