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Using <jats:italic>Xenopus laevis<\/jats:italic> embryos, we describe the spatial and temporal expression patterns during development of the 10 pore\u2010forming alpha1 subunits that define the channels' kinetic properties. In situ hybridization indicates that <jats:italic>Ca<jats:sub>V<\/jats:sub>1.2<\/jats:italic>, <jats:italic>Ca<jats:sub>V<\/jats:sub>2.1<\/jats:italic>, <jats:italic>Ca<jats:sub>V<\/jats:sub>2.2<\/jats:italic>, and <jats:italic>Ca<jats:sub>V<\/jats:sub>3.2<\/jats:italic> are expressed during neurula stages throughout the neural tube. These, along with <jats:italic>Ca<jats:sub>V<\/jats:sub>1.3<\/jats:italic> and <jats:italic>Ca<jats:sub>V<\/jats:sub>2.3<\/jats:italic>, beginning at early tail bud stages, and <jats:italic>Ca<jats:sub>V<\/jats:sub>3.1<\/jats:italic> at late tail bud stages, are detected in complex patterns within the brain and spinal cord through swimming tadpole stages. Additional expression of various alpha1 subunits was observed in the cranial ganglia, retina, olfactory epithelium, pineal gland, and heart. The unique expression patterns for the different alpha1 subunits suggests they are under precise spatial and temporal regulation and are serving specific functions during embryonic development. Developmental Dynamics 238:2891\u20132902, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.22102","type":"journal-article","created":{"date-parts":[[2009,9,30]],"date-time":"2009-09-30T17:31:56Z","timestamp":1254331916000},"page":"2891-2902","source":"Crossref","is-referenced-by-count":16,"title":["Cloning and characterization of voltage\u2010gated calcium channel alpha1 subunits in <i>Xenopus laevis<\/i> during development"],"prefix":"10.1002","volume":"238","author":[{"given":"Brittany B.","family":"Lewis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Wester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maitreyi D.","family":"Nagarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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